Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL541002 | 0.83 | HTT (0.70) | RPS6KB1ROCK1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4083024 | 0.82 | L3MBTL1 (0.56) | HTTSMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL4931125 | 0.82 | CYP19A1 (0.48) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL4095150 | 0.82 | SMN1; SMN2 (0.53) | HTTSMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL12730136 | 0.81 | MAPK1 (0.61) | RPS6KB1ROCK1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10353247 | 0.81 | RPS6KB1 (0.54) | RPS6KB1ROCK1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10894564 | 0.81 | RAB9A (0.51) | RPS6KB1ROCK1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8011388 | 0.80 | TP53 (0.66) | RPS6KB1ROCK1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4933492 | 0.80 | DCTPP1 (0.53) | HTTSMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL6912346 | 0.80 | ALDH1A1 (0.67) | RPS6KB1ROCK1HTTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10174052-B2 | Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-01-08 | — | — | US | disclosed |
| US-20170305929-A1 | QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | BRISTOL MYERS SQUIBB CO (US) | 2017-10-26 | — | — | US | disclosed |
| US-20090062317-A1 | MEDICINAL USE OF RECEPTOR LIGANDS | 7TM PHARMA A/S (DK) | 2009-03-05 | — | — | US | disclosed |
| EP-1778670-A2 | MEDICINAL USE OF RECEPTOR LIGANDS | 7TM Pharma A/S (DK) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006010446-A2 | MEDICINAL USE OF RECEPTOR LIGANDS | 7TM PHARMA A/S (DK) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10174052-B2 | Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands | CHRNA7, CHRNA5, CHRNA2 | RPS6KB1 2328/4885ROCK1 3246/4885HTT 2088/4885 |
| US-20090062317-A1 | MEDICINAL USE OF RECEPTOR LIGANDS | MCHR1, MCHR2, MC1R | RPS6KB1 1137/4885ROCK1 1927/4885HTT 907/4885 |
| US-20170305929-A1 | QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | CHRNA7, CHRNA5, CHRNA2 | RPS6KB1 2523/4885ROCK1 3685/4885HTT 2390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.