Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 19/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4350353 | 0.81 | HRH4 (0.45) | PARP1PTGS1PTGS2 | |
| SCHEMBL4358956 | 0.80 | PARP1 (0.45) | PARP1PARP2 | |
| SCHEMBL4344619 | 0.80 | PARP1 (0.42) | PARP1PARP2 | |
| SCHEMBL4350617 | 0.74 | HCRTR1 (0.38) | PARP1 | |
| SCHEMBL4097945 | 0.72 | HRH4 (0.47) | PARP1 | |
| SCHEMBL4358835 | 0.68 | SSTR5 (0.36) | PARP1 | |
| SCHEMBL605246 | 0.67 | HRH4 (0.67) | PARP1PARP2 | |
| SCHEMBL4348250 | 0.67 | LMNA (0.39) | — | |
| SCHEMBL4356661 | 0.67 | HRH4 (0.36) | — | |
| SCHEMBL4353639 | 0.66 | KDM4E (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069343-A1 | Combination Histamine H1R and H4R Antagonist Therapy for Treating Pruritus | DUNFORD PAUL J | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069343-A1 | Combination Histamine H1R and H4R Antagonist Therapy for Treating Pruritus | HRH4, HRH2, HRH3 | PARP1 1799/4885PARP2 2686/4885PTGS1 571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.