Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 18/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4350617 | 0.88 | HCRTR1 (0.38) | HRH4PARP1EGLN1 | |
| SCHEMBL4350353 | 0.80 | HRH4 (0.45) | HRH4PARP1 | |
| SCHEMBL4358835 | 0.79 | SSTR5 (0.36) | HRH4PARP1EGLN1 | |
| SCHEMBL4358956 | 0.77 | PARP1 (0.45) | PARP1 | |
| SCHEMBL4350354 | 0.77 | MPO (0.38) | HRH4PARP1 | |
| SCHEMBL4344619 | 0.77 | PARP1 (0.42) | PARP1 | |
| SCHEMBL4354354 | 0.76 | HRH4 (0.44) | HRH4EGLN1 | |
| SCHEMBL4348250 | 0.75 | LMNA (0.39) | HRH4 | |
| SCHEMBL4356635 | 0.74 | HRH4 (0.47) | HRH4 | |
| SCHEMBL4098540 | 0.72 | PARP1 (0.41) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069343-A1 | Combination Histamine H1R and H4R Antagonist Therapy for Treating Pruritus | DUNFORD PAUL J | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069343-A1 | Combination Histamine H1R and H4R Antagonist Therapy for Treating Pruritus | HRH4, HRH2, HRH3 | HRH4 1/4885PARP1 1799/4885EGLN1 1279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.