Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 12/20 | 0.36 |
| ▸ | PARP1 | P09874 | 3/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.31 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.31 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4354354 | 0.80 | HRH4 (0.44) | EGLN1HRH4DGAT1ADORA2AKCNH2 | |
| SCHEMBL4097945 | 0.79 | HRH4 (0.47) | PARP1EGLN1HRH4 | |
| SCHEMBL4350354 | 0.78 | MPO (0.38) | PARP1TNKSTNKS2HRH4 | |
| SCHEMBL4350353 | 0.73 | HRH4 (0.45) | PARP1HRH4 | |
| SCHEMBL4350617 | 0.73 | HCRTR1 (0.38) | PARP1EGLN1HRH4 | |
| SCHEMBL4353639 | 0.73 | KDM4E (0.40) | — | |
| SCHEMBL4358956 | 0.72 | PARP1 (0.45) | PARP1 | |
| SCHEMBL4098296 | 0.72 | HRH4 (0.43) | PARP1HRH4DGAT1ADORA2AKCNH2 | |
| SCHEMBL4344619 | 0.72 | PARP1 (0.42) | PARP1 | |
| SCHEMBL4356646 | 0.72 | HRH4 (0.45) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504426-B2 | Heterocyclic compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-17 | — | — | US | disclosed |