Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4350353 | 0.86 | HRH4 (0.45) | PARP1GAA | |
| SCHEMBL4344619 | 0.85 | PARP1 (0.42) | PARP1PARP2 | |
| SCHEMBL4098540 | 0.80 | PARP1 (0.41) | PARP1PARP2 | |
| SCHEMBL4350617 | 0.79 | HCRTR1 (0.38) | PARP1 | |
| SCHEMBL4097945 | 0.77 | HRH4 (0.47) | PARP1 | |
| SCHEMBL4358835 | 0.72 | SSTR5 (0.36) | PARP1 | |
| SCHEMBL4348250 | 0.71 | LMNA (0.39) | MEN1POLBMAPTKMT2A | |
| SCHEMBL31047345 | 0.70 | POLB (0.53) | PARP1PARP2MEN1POLBGAA | |
| SCHEMBL4353639 | 0.70 | KDM4E (0.40) | MEN1POLBGAAMAPTKMT2A | |
| SCHEMBL4352227 | 0.70 | HRH4 (0.35) | MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068211-A1 | TRICYCLIC INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-24 | — | — | WO | disclosed |
| US-7504426-B2 | Heterocyclic compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-17 | — | — | US | disclosed |