Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4350353 | 0.86 | HRH4 (0.45) | PARP1HCRTR1HCRTR2 | |
| SCHEMBL4358956 | 0.85 | PARP1 (0.45) | PARP1PARP2 | |
| SCHEMBL4098540 | 0.80 | PARP1 (0.41) | PARP1PARP2 | |
| SCHEMBL4350617 | 0.79 | HCRTR1 (0.38) | PARP1HCRTR1HCRTR2 | |
| SCHEMBL4356646 | 0.77 | HRH4 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL4097945 | 0.77 | HRH4 (0.47) | PARP1 | |
| SCHEMBL4356635 | 0.75 | HRH4 (0.47) | — | |
| SCHEMBL4103942 | 0.74 | KCNH2 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL4358835 | 0.72 | SSTR5 (0.36) | PARP1 | |
| SCHEMBL4348250 | 0.71 | LMNA (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504426-B2 | Heterocyclic compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-17 | — | — | US | disclosed |