Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 5/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.38 |
| ▸ | MGAM | O43451 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 5/20 | 0.38 |
| ▸ | SI | P14410 | 5/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4358956 | 0.86 | PARP1 (0.45) | PARP1GAA | |
| SCHEMBL4344619 | 0.86 | PARP1 (0.42) | PARP1HCRTR1HCRTR2 | |
| SCHEMBL4350617 | 0.85 | HCRTR1 (0.38) | HRH4PARP1HCRTR1HCRTR2 | |
| SCHEMBL4098540 | 0.81 | PARP1 (0.41) | PARP1PTGS1PTGS2 | |
| SCHEMBL4097945 | 0.80 | HRH4 (0.47) | HRH4PARP1 | |
| SCHEMBL2201563 | 0.77 | MGAM (0.40) | PDE10APTGS1PTGS2HCRTR1HCRTR2 | |
| SCHEMBL4353639 | 0.76 | KDM4E (0.40) | HCRTR1HCRTR2GAA | |
| SCHEMBL4348250 | 0.74 | LMNA (0.39) | HRH4PDE10A | |
| SCHEMBL4358835 | 0.73 | SSTR5 (0.36) | HRH4PARP1 | |
| SCHEMBL4103942 | 0.72 | KCNH2 (0.40) | HRH4HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504426-B2 | Heterocyclic compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-17 | — | — | US | disclosed |