Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 2/20 | 0.30 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.30 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.30 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15447693 | 0.91 | HPGD (0.31) | TSHRHPGD | |
| SCHEMBL12113738 | 0.90 | TSHR (0.36) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL410384 | 0.90 | TSHR (0.36) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL12131534 | 0.83 | TSHR (0.33) | TSHRHPGDPRKCAPRKCEPRKCQ | |
| SCHEMBL409950 | 0.82 | PRKCA (0.32) | TSHRPRKCAPRKCEPRKCQPRKCD | |
| SCHEMBL15447691 | 0.82 | HPGD (0.30) | TSHRHPGD | |
| SCHEMBL14824482 | 0.81 | TSHR (0.51) | TSHRHPGDPRKCAPRKCEPRKCQ | |
| Water SCHEMBL10950542 | 0.79 | TSHR (0.50) | TSHRHPGDPRKCAPRKCEPRKCQ | |
| Acrylic Acid SCHEMBL1285971 | 0.78 | USP2 (0.41) | — | |
| SCHEMBL411296 | 0.78 | TSHR (0.41) | TSHRHPGDALDH1A1TP53HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9921340-B2 | Water-processable silicone-containing prepolymers and uses thereof | NOVARTIS AG (CH) | 2018-03-20 | — | — | US | disclosed |
| US-20160033683-A1 | WATER-PROCESSABLE SILICONE-CONTAINING PREPOLYMERS AND USES THEREOF | ALCON INC. (CH) | 2016-02-04 | — | — | US | disclosed |
| US-9187601-B2 | Water-processable silicone-containing prepolymers and uses thereof | NOVARTIS AG (CH) | 2015-11-17 | — | — | US | disclosed |
| US-8637589-B2 | Silicone prepolymer solutions | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2014-01-28 | — | — | US | disclosed |
| US-8569538-B2 | Acryloyl materials for molded plastics | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-8569538-B2 | Acryloyl materials for molded plastics | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-8399539-B2 | Soluble silicone prepolymers | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2013-03-19 | — | — | US | disclosed |
| US-20120088861-A1 | WATER-PROCESSABLE SILICONE-CONTAINING PREPOLYMERS AND USES THEREOF | ALCON INC. (CH) | 2012-04-12 | — | — | US | disclosed |
| US-20120065348-A1 | SOLUBLE SILICONE PREPOLYMERS | TORAY INDUSTRIES, INC. (JP) | 2012-03-15 | — | — | US | disclosed |
| US-8080622-B2 | Soluble silicone prepolymers | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2011-12-20 | — | — | US | disclosed |
| US-8080622-B2 | Soluble silicone prepolymers | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2011-12-20 | — | — | US | disclosed |
| US-8053539-B2 | Prepared by purifying acrylic siloxanyl containing monomers by distillation in the presence of at least one polymerization inhibitor which can be an alkylhydroquinone or a hydroxynaphthalene; without substantial amounts of polymerization product(s) and without discoloration; contact lenses | JOHNSON & JOHNSON VISION CARE INC. (US) | 2011-11-08 | — | — | US | disclosed |
| US-20110077322-A1 | Silicone Prepolymer Solutions | TORAY INDUSTRIES, INC. (JP) | 2011-03-31 | — | — | US | disclosed |
| US-7897654-B2 | Silicone prepolymer solutions | JOHNSON & JOHNSON VISION CARE INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-20090171026-A1 | SILICONE PREPOLYMER SOLUTIONS | JOHNSON & JOHNSON VISION CARE, INC. | 2009-07-02 | — | — | US | disclosed |
| US-20090005528-A1 | SOLUBLE SILICONE PREPOLYMERS | JOHNSON & JOHNSON VISION CARE, INC. | 2009-01-01 | — | — | US | disclosed |
| US-20080004401-A1 | SILOXANYL MATERIALS FOR MOLDED PLASTICS | JOHNSON & JOHNSON VISION CARE, INC. | 2008-01-03 | — | — | US | disclosed |
| US-20080004383-A1 | ACRYLOYL MATERIALS FOR MOLDED PLASTICS | TORAY INDUSTRIES, INC. (JP) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005528-A1 | SOLUBLE SILICONE PREPOLYMERS | NOS3, NOS2, PCNA | TSHR 4182/4885HPGD 97/4885ALDH1A1 2292/4885 |
| US-20080004383-A1 | ACRYLOYL MATERIALS FOR MOLDED PLASTICS | ACR, HAAO, PORCN | TSHR 4861/4885HPGD 583/4885ALDH1A1 515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.