Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 4/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.41 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 4/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8705477 | 0.85 | KDM4E (0.47) | ADORA1ADORA3ADORA2AADORA2BSLC6A3 | |
| SCHEMBL7279899 | 0.83 | ADORA1 (0.44) | ADORA1ADORA3ADORA2AADORA2BSLC6A3 | |
| SCHEMBL14267083 | 0.82 | LMNA (0.41) | ADORA1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7279799 | 0.81 | CNR2 (0.40) | ADORA1ADORA3ADORA2AADORA2BSLC6A3 | |
| SCHEMBL8705434 | 0.78 | ADORA1 (0.39) | ADORA1ADORA3ADORA2AADORA2BSLC6A3 | |
| SCHEMBL8208161 | 0.77 | ALDH1A1 (0.40) | ADORA1ADORA3ADORA2AADORA2BSLC6A3 | |
| SCHEMBL7436318 | 0.77 | ADORA1 (0.46) | ADORA1ADORA3ADORA2AADORA2BSLC6A3 | |
| SCHEMBL7269080 | 0.76 | CNR2 (0.39) | ADORA1ADORA3ADORA2AADORA2BSLC6A3 | |
| SCHEMBL8397308 | 0.75 | ADORA2A (0.42) | ADORA1ADORA3ADORA2AADORA2BSLC6A3 | |
| SCHEMBL12079923 | 0.74 | ADORA1 (0.52) | ADORA1ADORA3ADORA2AADORA2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061793-A2 | KW-3902 CONJUGATES THAT DO NOT CROSS THE BLOOD-BRAIN BARRIER | Novacardia, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| US-20080070934-A1 | KW-3902 CONJUGATES THAT DO NOT CROSS THE BLOOD-BRAIN BARRIER | MUGERDITICHIAN MARK | 2008-03-20 | — | — | US | disclosed |
| US-20080070934-A1 | KW-3902 CONJUGATES THAT DO NOT CROSS THE BLOOD-BRAIN BARRIER | MUGERDITICHIAN MARK | 2008-03-20 | — | — | US | disclosed |
| US-20080070934-A1 | KW-3902 CONJUGATES THAT DO NOT CROSS THE BLOOD-BRAIN BARRIER | MUGERDITICHIAN MARK | 2008-03-20 | — | — | US | disclosed |
| WO-2008024277-A2 | KW-3902 CONJUGATES THAT DO NOT CROSS THE BLOOD-BRAIN BARRIER | NOVACARDIA, INC. (US) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008024277-A2 | KW-3902 CONJUGATES THAT DO NOT CROSS THE BLOOD-BRAIN BARRIER | NOVACARDIA, INC. (US) | 2008-02-28 | — | — | WO | disclosed |
| EP-0415456-B1 | Xanthine compounds | KYOWA HAKKO KOGYO KK (JP) | 1996-06-26 | — | — | EP | disclosed |
| US-5525607-A | DIURETICS, BRONCHODILATORS, RENAL PROTECTING AGENTS | KYOWA HAKKO KOGYO CO., LTD (JP) | 1996-06-11 | — | — | US | disclosed |
| US-5290782-A | Bronchodilator agents, diuretics for renal protective agents | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070934-A1 | KW-3902 CONJUGATES THAT DO NOT CROSS THE BLOOD-BRAIN BARRIER | DCX, FLT4, KDR | ADORA1 637/4885ADORA3 227/4885ADORA2A 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.