Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.38 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7279899 | 0.91 | ADORA1 (0.44) | ADORA2AADORA2BADORA1ADORA3SLC6A3 | |
| SCHEMBL8397023 | 0.86 | ADORA2B (0.44) | ADORA2AADORA2BADORA1ADORA3GAA | |
| SCHEMBL8208161 | 0.85 | ALDH1A1 (0.40) | ADORA2AADORA2BADORA1ADORA3SLC6A3 | |
| SCHEMBL7436318 | 0.85 | ADORA1 (0.46) | ADORA2AADORA2BADORA1ADORA3SLC6A3 | |
| SCHEMBL8705434 | 0.84 | ADORA1 (0.39) | ADORA2AADORA2BADORA1ADORA3SLC6A3 | |
| SCHEMBL7279799 | 0.81 | CNR2 (0.40) | ADORA2AADORA2BADORA1ADORA3SLC6A3 | |
| SCHEMBL7269080 | 0.80 | CNR2 (0.39) | ADORA2AADORA2BADORA1ADORA3SLC6A3 | |
| SCHEMBL7270332 | 0.80 | DHFR (0.48) | ADORA2AADORA2BADORA1ADORA3SLC6A3 | |
| SCHEMBL8710355 | 0.80 | TDP1 (0.35) | ADORA2AADORA2BADORA1ADORA3SLC6A3 | |
| SCHEMBL8706002 | 0.76 | ADORA1 (0.36) | ADORA2AADORA2BADORA1ADORA3SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0541120-B1 | Xanthine derivatives for the treatment of dementia | KYOWA HAKKO KOGYO KK (JP) | 1999-05-26 | — | — | EP | disclosed |
| US-5447933-A | Antidementia activity | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-09-05 | — | — | US | disclosed |
| US-5336769-A | Anti-dementia drug | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-09 | — | — | US | disclosed |
| EP-0556778-A2 | Xanthine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-08-25 | — | — | EP | disclosed |