Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.36 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7279899 | 0.89 | ADORA1 (0.44) | CNR2CNR1ADORA1ADORA3ADORA2A | |
| SCHEMBL8705434 | 0.85 | ADORA1 (0.39) | CNR2CNR1ADORA1ADORA3ADORA2A | |
| SCHEMBL7436318 | 0.83 | ADORA1 (0.46) | CNR2CNR1ADORA1ADORA3ADORA2A | |
| SCHEMBL7269080 | 0.82 | CNR2 (0.39) | CNR2CNR1ADORA1ADORA3ADORA2A | |
| SCHEMBL8705477 | 0.81 | KDM4E (0.47) | CNR2CNR1ADORA1ADORA3ADORA2A | |
| SCHEMBL4105083 | 0.81 | ADORA1 (0.41) | CNR2CNR1ADORA1ADORA3ADORA2A | |
| SCHEMBL8397308 | 0.81 | ADORA2A (0.42) | CNR2CNR1ADORA1ADORA3ADORA2A | |
| SCHEMBL8208161 | 0.81 | ALDH1A1 (0.40) | ADORA1ADORA3ADORA2AADORA2BSLC6A3 | |
| SCHEMBL7270332 | 0.78 | DHFR (0.48) | CNR2CNR1ADORA1ADORA3ADORA2A | |
| SCHEMBL8710355 | 0.77 | TDP1 (0.35) | ADORA1ADORA3ADORA2AADORA2BSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415456-B1 | Xanthine compounds | KYOWA HAKKO KOGYO KK (JP) | 1996-06-26 | — | — | EP | disclosed |
| US-5525607-A | DIURETICS, BRONCHODILATORS, RENAL PROTECTING AGENTS | KYOWA HAKKO KOGYO CO., LTD (JP) | 1996-06-11 | — | — | US | disclosed |
| US-5290782-A | Bronchodilator agents, diuretics for renal protective agents | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-03-01 | — | — | US | disclosed |
| EP-0415456-A2 | Xanthine compounds | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-03-06 | — | — | EP | disclosed |