Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 6/20 | 0.44 |
| ▸ | VNN1 | O95497 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3943937 | 0.89 | NPY5R (0.47) | NPY5RVNN1GAANPY2R | |
| SCHEMBL3946248 | 0.84 | NPY5R (0.42) | NPY5RHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL3951253 | 0.77 | NPY5R (0.46) | NPY5RGAANPY2R | |
| SCHEMBL1383650 | 0.75 | LMNA (0.43) | HDAC3HDAC1HDAC2HDAC6CCNA2 | |
| SCHEMBL3442663 | 0.71 | HDAC3 (0.52) | VNN1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL3946609 | 0.67 | NPY5R (0.43) | NPY5RGAA | |
| SCHEMBL3948201 | 0.66 | SLC6A2 (0.37) | LMNASYKAURKBINCENP | |
| SCHEMBL3942976 | 0.66 | CASR (0.41) | VNN1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL3390661 | 0.66 | GAA (0.54) | NPY5RGAANPY2RKDM4ELMNA | |
| SCHEMBL13819023 | 0.66 | GAA (0.54) | NPY5RGAANPY2RKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718632-B1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2009-04-22 | — | — | EP | claimed |