Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | ACR | P10323 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ESRRG | P62508 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL440528 | 0.86 | ALDH1A1 (0.50) | ALDH1A1TAS1R3TAS1R1NPC1MAPT | |
| SCHEMBL9699988 | 0.86 | CYP2C9 (0.52) | ALDH1A1KDM4EMAPK1TYRSMN1; SMN2 | |
| SCHEMBL24512104 | 0.84 | TAS1R3 (0.43) | ALDH1A1TAS1R3TAS1R1SMN1; SMN2NPC1 | |
| SCHEMBL463760 | 0.81 | TDP1 (0.52) | ALDH1A1KDM4ETAS1R3TAS1R1SMN1; SMN2 | |
| SCHEMBL367595 | 0.80 | TYR (0.58) | ALDH1A1KDM4EMAPK1TYRSMN1; SMN2 | |
| SCHEMBL440529 | 0.79 | F2 (0.48) | ALDH1A1MAPK1RAB9AMAPTPOLB | |
| SCHEMBL9699992 | 0.79 | TSHR (0.50) | ALDH1A1SMN1; SMN2NPC1RAB9APRSS1 | |
| Methane SCHEMBL11025053 | 0.78 | TYR (0.56) | ALDH1A1KDM4EMAPK1TYRSMN1; SMN2 | |
| SCHEMBL8965237 | 0.78 | KDM4E (0.58) | ALDH1A1KDM4EMAPK1SMN1; SMN2NPC1 | |
| SCHEMBL27618266 | 0.77 | TNFRSF1A (0.46) | ALDH1A1MAPK1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637589-B2 | Silicone prepolymer solutions | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2014-01-28 | — | — | US | disclosed |
| US-8399539-B2 | Soluble silicone prepolymers | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2013-03-19 | — | — | US | disclosed |
| US-8399539-B2 | Soluble silicone prepolymers | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2013-03-19 | — | — | US | disclosed |
| US-20120065348-A1 | SOLUBLE SILICONE PREPOLYMERS | TORAY INDUSTRIES, INC. (JP) | 2012-03-15 | — | — | US | disclosed |
| US-20120065348-A1 | SOLUBLE SILICONE PREPOLYMERS | TORAY INDUSTRIES, INC. (JP) | 2012-03-15 | — | — | US | disclosed |
| US-8080622-B2 | Soluble silicone prepolymers | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2011-12-20 | — | — | US | disclosed |
| US-20110077322-A1 | Silicone Prepolymer Solutions | TORAY INDUSTRIES, INC. (JP) | 2011-03-31 | — | — | US | disclosed |
| US-7897654-B2 | Silicone prepolymer solutions | JOHNSON & JOHNSON VISION CARE INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-20090171026-A1 | SILICONE PREPOLYMER SOLUTIONS | JOHNSON & JOHNSON VISION CARE, INC. | 2009-07-02 | — | — | US | disclosed |
| US-20090005528-A1 | SOLUBLE SILICONE PREPOLYMERS | JOHNSON & JOHNSON VISION CARE, INC. | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005528-A1 | SOLUBLE SILICONE PREPOLYMERS | NOS3, NOS2, PCNA | ALDH1A1 2292/4885KDM4E 3647/4885MAPK1 3212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.