SCHEMBL41195

SCHEMBL41195

c1ccc(C[Si](Cc2ccccc2)Cc2ccccc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CALM1 P0DP23 1/20 0.50
TSHR P16473 4/20 0.45
ALDH1A1 P00352 3/20 0.45
IDO1 P14902 3/20 0.45
LOXL2 Q9Y4K0 2/20 0.45
TP53 P04637 1/20 0.45
TRPA1 O75762 1/20 0.45
MAOB P27338 1/20 0.43
HPGD P15428 1/20 0.43
ALOX15 P16050 1/20 0.43
ALOX12 P18054 1/20 0.43
CASP1 P29466 1/20 0.43
HSD17B10 Q99714 1/20 0.43
TDP1 Q9NUW8 2/20 0.41
CYP2A6 P11509 1/20 0.41
HTR2A P28223 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
TAAR1 Q96RJ0 1/20 0.41
THRB P10828 1/20 0.39
EPHX2 P34913 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9075638 0.83 TP53 (0.50) CALM1TSHRALDH1A1IDO1LOXL2
SCHEMBL6960730 0.75 TP53 (0.48) CALM1TSHRALDH1A1IDO1LOXL2
SCHEMBL703494 0.75 CALM1 (0.45) CALM1TSHRALDH1A1IDO1LOXL2
SCHEMBL476127 0.75 PTGS1 (0.48) CALM1TSHRALDH1A1IDO1LOXL2
SCHEMBL703317 0.75 CALM1 (0.45) CALM1TSHRALDH1A1IDO1LOXL2
SCHEMBL8992221 0.73 CALM1 (0.43) CALM1TSHRALDH1A1IDO1LOXL2
SCHEMBL8992232 0.73 CALM1 (0.43) CALM1TSHRALDH1A1IDO1LOXL2
SCHEMBL16298659 0.71 TP53 (0.43) CALM1TSHRALDH1A1IDO1LOXL2
SCHEMBL8575145 0.71 TP53 (0.50) CALM1TSHRALDH1A1IDO1LOXL2
SCHEMBL22319082 0.69 SLC6A2 (0.44) CALM1TSHRALDH1A1IDO1LOXL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8034 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240228527-A1 STEREOSELECTIVE C9-C10 BOND FORMATION TRUSTEES OF DARTMOUTH COLLEGE 2024-07-11 US claimed
US-20240182516-A1 METHODS FOR CONVENIENT ASYMMETRIC SYNTHESIS OF C9-SUBSTITUTED STEROID-LIKE COMPOUNDS TRUSTEES OF DARTMOUTH COLLEGE 2024-06-06 US claimed
EP-2991655-B1 COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2024-04-10 EP claimed
US-20230406878-A1 OLIGONUCLEOTIDES, REAGENTS, AND PREPARATION THEREOF BIOGEN MA INC. 2023-12-21 US claimed
CN-110678447-B Modified nucleic acid monomer compounds and oligonucleotide analogues 卫材R&D管理有限公司 2023-12-12 CN claimed
CN-116940582-A Oligonucleotides, reagents and their preparation 渤健马萨诸塞州股份有限公司 2023-10-24 CN claimed
EP-3606528-B1 TRICYCLIC COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK3) INHIBITORS AND USES THEREOF BROAD INST INC (US) 2023-10-18 EP claimed
EP-4244232-A1 OLIGONUCLEOTIDES, REAGENTS AND PREPARATION THEREOF Biogen MA Inc. (US) 2023-09-20 EP claimed
CN-111318303-B Phenolate and application thereof 中国科学院上海有机化学研究所 2023-08-11 CN claimed
CN-116444968-A Modified polylactic acid composite film and manufacturing process thereof 四川武匀德新材料科技有限公司 2023-07-18 CN claimed
US-4444788-A Pharmaceutically active 9-chloroprostaglandins SCHERING AKTIENGESELLSCHAFT (DE) 1984-04-24 US claimed
EP-0105267-A1 METHOD FOR THE PREPARATION OF INTERMEDIARY COMPOUNDS OF CARBACYCLIN. SCHERING AG (DE) 1984-04-18 EP claimed
EP-0099850-A1 Novel carbacyclin esters, process for the preparation thereof, and their use as medicinal agents SCHERING AKTIENGESELLSCHAFT (DE) 1984-02-01 EP claimed
US-4416985-A Process for preparing 3β,7β-dihydroxy-Δ5 -steroids SCHERING, AKTIENGESELLSCHAFT (DE) 1983-11-22 US claimed
WO-1983001449-A1 METHOD FOR THE PREPARATION OF INTERMEDIARY COMPOUNDS OF CARBACYCLIN VORBRÜGGEN, Helmut 1983-04-28 WO claimed
US-4364951-A Prostacyclins and use as medicinal agents SCHERING AKTIENGESELLSCHAFT (DE) 1982-12-21 US claimed
US-4364950-A 5-Cyano-prostacyclin derivatives and use as medicines SCHERING AKTIENGESELLSCHAFT (DE) 1982-12-21 US claimed
US-4315013-A Certain pyrrole analogs of prostacyclin derivatives SCHERING, AKTIENGESELLSCHAFT (DE) 1982-02-09 US claimed
US-4310459-A Process for producing carbamoyl substituted penams and carbamoyl substituted cephams from penicillin sulfoxide esters BRISTOL-MYERS COMPANY (US) 1982-01-12 US claimed
US-4219479-A STABILIZED PROSTACYCLINS, HYPOTENSIVE AGENTS SCHERING AKTIENGESELLSCHAFT (DE) 1980-08-26 US claimed