SCHEMBL8992232

SCHEMBL8992232

c1ccc(C[Si](c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CALM1 P0DP23 1/20 0.43
TSHR P16473 4/20 0.39
ALDH1A1 P00352 3/20 0.39
IDO1 P14902 3/20 0.39
LOXL2 Q9Y4K0 2/20 0.39
TP53 P04637 1/20 0.39
TRPA1 O75762 1/20 0.39
MAOB P27338 1/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38
ALOX12 P18054 1/20 0.38
CASP1 P29466 1/20 0.38
HSD17B10 Q99714 1/20 0.38
TDP1 Q9NUW8 2/20 0.36
CYP2A6 P11509 1/20 0.36
HTR2A P28223 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
TAAR1 Q96RJ0 1/20 0.36
THRB P10828 1/20 0.35
EPHX2 P34913 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8992221 0.78 CALM1 (0.43) CALM1TSHRALDH1A1IDO1LOXL2
SCHEMBL8992235 0.74 TP53 (0.42) CALM1TSHRALDH1A1IDO1LOXL2
SCHEMBL41195 0.73 CALM1 (0.50) CALM1TSHRALDH1A1IDO1LOXL2
SCHEMBL703494 0.69 CALM1 (0.45) CALM1TSHRALDH1A1IDO1LOXL2
SCHEMBL6960730 0.69 TP53 (0.48) CALM1TSHRALDH1A1IDO1LOXL2
SCHEMBL416584 0.69 TP53 (0.41) CALM1TSHRALDH1A1IDO1TP53
SCHEMBL476127 0.69 PTGS1 (0.48) CALM1TSHRALDH1A1IDO1LOXL2
SCHEMBL703317 0.69 CALM1 (0.45) CALM1TSHRALDH1A1IDO1LOXL2
SCHEMBL7640554 0.69 CALM1 (0.32) CALM1ALDH1A1
SCHEMBL7628010 0.69 CALM1 (0.32) CALM1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5516871-A Diphenylsiloxane oligomers functionalized at both terminals and methods for the preparation thereof DOW CORNING ASIA, LTD. (JP) 1996-05-14 US claimed
US-5502229-A ENDCAPPING DOW CORNING ASIA, LTD. (JP) 1996-03-26 US claimed
CN-109790161-B Pyrazolopyridine derivatives having GLP-1 receptor agonist action 中外制药株式会社 2022-03-11 CN disclosed
US-10038143-B2 Polymer compound, material for electronic elements, material for organic electroluminescent elements, and organic electroluminescent element IDEMITSU KOSAN CO., LTD. (JP) 2018-07-31 US disclosed
US-20180090687-A1 CROSS-CONJUGATED POLYMER, MATERIAL FOR ELECTRONIC ELEMENT, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT, AND ORGANIC ELECTROLUMINESCENT ELEMENT IDEMITSU KOSAN CO., LTD (JP) 2018-03-29 US disclosed
US-20150249215-A1 POLYMER COMPOUND, MATERIAL FOR ELECTRONIC ELEMENTS, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENTS, AND ORGANIC ELECTROLUMINESCENT ELEMENT IDEMITSU KOSAN CO., LTD. (JP) 2015-09-03 US disclosed
US-5516871-A Diphenylsiloxane oligomers functionalized at both terminals and methods for the preparation thereof DOW CORNING ASIA, LTD. (JP) 1996-05-14 US disclosed
US-5502229-A ENDCAPPING DOW CORNING ASIA, LTD. (JP) 1996-03-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180090687-A1 CROSS-CONJUGATED POLYMER, MATERIAL FOR ELECTRONIC ELEMENT, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT, AND ORGANIC ELECTROLUMINESCENT ELEMENT SLC18A1, SLC1A2, SLC43A1 CALM1 2425/4885TSHR 3534/4885ALDH1A1 764/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.