SCHEMBL476127

SCHEMBL476127

C[Si](C)Cc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.48
PTGS2 P35354 1/20 0.48
TP53 P04637 1/20 0.48
CALM1 P0DP23 1/20 0.45
TSHR P16473 4/20 0.42
ALDH1A1 P00352 4/20 0.42
TDP1 Q9NUW8 2/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
IDO1 P14902 1/20 0.41
LOXL2 Q9Y4K0 1/20 0.41
TRPA1 O75762 1/20 0.41
KDM4E B2RXH2 2/20 0.40
CYP3A4 P08684 1/20 0.40
MAPT P10636 1/20 0.40
MAOB P27338 1/20 0.39
HPGD P15428 1/20 0.39
ALOX15 P16050 1/20 0.39
ALOX12 P18054 1/20 0.39
CASP1 P29466 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6960730 0.82 TP53 (0.48) TP53CALM1TSHRALDH1A1TDP1
SCHEMBL16298659 0.78 TP53 (0.43) TP53CALM1TSHRALDH1A1IDO1
SCHEMBL8575145 0.78 TP53 (0.50) TP53CALM1TSHRALDH1A1TDP1
SCHEMBL8992235 0.76 TP53 (0.42) TP53CALM1TSHRALDH1A1TDP1
SCHEMBL41195 0.75 CALM1 (0.50) TP53CALM1TSHRALDH1A1TDP1
SCHEMBL9075638 0.72 TP53 (0.50) TP53CALM1TSHRALDH1A1TDP1
SCHEMBL476137 0.72 ALDH1A1 (0.48) TP53ALDH1A1TDP1LOXL2MAOB
SCHEMBL703317 0.71 CALM1 (0.45) TP53CALM1TSHRALDH1A1TDP1
SCHEMBL703494 0.71 CALM1 (0.45) TP53CALM1TSHRALDH1A1TDP1
SCHEMBL8865473 0.70 TAAR1 (0.44) TP53CALM1TSHRTRPA1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 394 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119490523-A Quaternary carbon chiral allylgem-silicon boron compound, synthesis method thereof and application thereof in allylboration reaction 四川大学 2025-02-21 CN claimed
WO-2023161688-A1 SILA-ANALOGUES OF VITAMIN D COMPOUNDS, METHOD OF PRODUCING SAID COMPOUNDS AND USES THEREOF REQUIMTE - REDE DE QUÍMICA E TECNOLOGIA (PT) 2023-08-31 WO claimed
CN-114206334-A Process for preparing aminopyrimidine compounds 艾库斯生物科学有限公司 2022-03-18 CN claimed
WO-2020247789-A1 PROCESSES FOR PREPARING AMINOPYRIMIDINE COMPOUNDS ARCUS BIOSCIENCES, INC. (US) 2020-12-10 WO claimed
CN-106748690-A A kind of iron catalysis oxidation alkene synthesizes the method for ketone 南京师范大学 2017-05-31 CN claimed
EP-2267046-B1 Process for homo- or copolymerization of conjugated olefines STYRON EUROPE GMBH (CH) 2013-08-07 EP claimed
US-20110213168-A1 DEUTERATED VITAMIN D COMPOUNDS UNIVERSIDADE DE SANTIAGO DE COMPOSTELA (ES) 2011-09-01 US claimed
EP-2360154-A1 DEUTERATED VITAMIN D COMPOUNDS Universidade De Santiago De Compostela (ES) 2011-08-24 EP claimed
EP-2267046-A1 Process for homo- or copolymerization of conjugated olefines DOW GLOBAL TECHNOLOGIES INC. (US) 2010-12-29 EP claimed
US-20100248947-A1 PROCESS FOR HOMO - OR COPOLYMERIZATION OF CONJUGATED OLEFINS DOW GLOBAL TECHNOLOGIES INC. (US) 2010-09-30 US claimed
EP-0817774-A1 CYCLOHEXYLAMINO AND CYCLOHEXYLALKOXY NITROGEN HETEROCYCLES, METHODS OF PREPARING THEM AND THEIR USE AS PEST-CONTROL AGENTS AND FUNGICIDES Hoechst Schering AgrEvo GmbH (DE) 1998-01-14 EP claimed
EP-0793497-A1 NOVEL ENEDIYNE QUINONE IMINES AND METHODS OF PREPARATION AND USE THEREOF Sloan-Kettering Institute For Cancer Research (US) 1997-09-10 EP claimed
WO-1996030345-A1 CYCLOHEXYLAMINO AND CYCLOHEXYLALKOXY NITROGEN HETEROCYCLES, METHODS OF PREPARING THEM AND THEIR USE AS PEST-CONTROL AGENTS AND FUNGICIDES HOECHST SCHERING AGREVO GMBH (DE) 1996-10-03 WO claimed
WO-1996016655-A1 NOVEL ENEDIYNE QUINONE IMINES AND METHODS OF PREPARATION AND USE THEREOF SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1996-06-06 WO claimed
US-5516871-A Diphenylsiloxane oligomers functionalized at both terminals and methods for the preparation thereof DOW CORNING ASIA, LTD. (JP) 1996-05-14 US claimed
US-5502229-A ENDCAPPING DOW CORNING ASIA, LTD. (JP) 1996-03-26 US claimed
EP-0291787-B1 Novel substituted silyl alkylene amines MERRELL DOW PHARMA (US) 1994-03-16 EP claimed
US-5164525-A SYNTHETIC PROCESS FOR FK-506 TYPE MACROLIDE INTERMEDIATES MERCK & CO., INC. (US) 1992-11-17 US claimed
EP-0405994-A2 Synthetic process for FK-506 type macrolide intermediates MERCK & CO. INC. (US) 1991-01-02 EP claimed
EP-0291787-A1 Novel substituted silyl alkylene amines MERRELL DOW PHARMACEUTICALS INC. (US) 1988-11-23 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110213168-A1 DEUTERATED VITAMIN D COMPOUNDS CYP24A1, VDR, CYP2R1 PTGS1 2892/4885PTGS2 3741/4885TP53 4009/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.