SCHEMBL4124729

SCHEMBL4124729

C#Cc1cc([Si](C)(C)C)ccc1C=O

nearest known ligand 0.30

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 1/20 0.30
ACHE P22303 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28439449 0.82
SCHEMBL9538187 0.77 ACHE (0.32) ACHE
SCHEMBL8743280 0.77 TDP1 (0.40) ACHEALDH1A1
SCHEMBL5014204 0.73 EGFR (0.31) ACHE
SCHEMBL22686914 0.73 TDP1 (0.33)
SCHEMBL3970050 0.72 TYR (0.52) ACHE
SCHEMBL28362746 0.72 ACHE (0.33) ACHE
SCHEMBL22687457 0.72 TDP1 (0.55) ALDH1A1
SCHEMBL5747733 0.72 ALDH1A1 (0.39) ALDH1A1
SCHEMBL8018559 0.72 EGFR (0.35) ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104017123-B Thermo-sensitive type polyphenylacetylene and preparation method thereof 上海大学 2017-02-01 CN claimed
CN-117616337-A Film forming material for semiconductor, member forming material for semiconductor, process member forming material for semiconductor, underlayer film forming material, underlayer film, and semiconductor device 株式会社艾迪科 2024-02-27 CN disclosed
CN-116490526-A Compounds and compositions 株式会社艾迪科 2023-07-25 CN disclosed
CN-104017123-B Thermo-sensitive type polyphenylacetylene and preparation method thereof 上海大学 2017-02-01 CN disclosed
US-20090124624-A1 SUBSTITUTED 1-AMINOPHTHALAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF SANOFI-AVENTIS (FR) 2009-05-14 US disclosed
EP-1940823-A2 SUBSTITUTED 1-AMINO-PHTHALZINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF Sanofi-Aventis (FR) 2008-07-09 EP disclosed
WO-2007042660-A2 SUBSTITUTED 1-AMINO-PHTHALZINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2007-04-19 WO disclosed
US-6797390-B2 PHOSPHOR BONDED TO ACETYLENE COPOLYMER NATIONAL AEROSPACE LABORATORY OF JAPAN (JP) 2004-09-28 US disclosed
US-20030175511-A1 Functional polymer with supported pressure-sensitive luminophore, and pressure-sensitive paint and pressure-sensitive element using same NATIONAL AEROSPACE LABORATORY (JP) 2003-09-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090124624-A1 SUBSTITUTED 1-AMINOPHTHALAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AGTR1, AGTR2, AHR ABL1 133/4885ACHE 2862/4885ALDH1A1 60/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.