Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | CASP1 | P29466 | 2/20 | 0.31 |
| ▸ | CASP7 | P55210 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4125201 | 0.77 | PDE5A (0.36) | KDM4EHSD17B10TSHRNPSR1ALDH1A1 | |
| SCHEMBL4123024 | 0.70 | ALDH1A1 (0.36) | KDM4EHSD17B10TSHRNPSR1ALDH1A1 | |
| SCHEMBL4125200 | 0.64 | PDE4B (0.34) | KDM4EHSD17B10TSHRNPSR1ALDH1A1 | |
| SCHEMBL8041296 | 0.63 | PDE5A (0.48) | HSD17B10ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL8043288 | 0.62 | RAB9A (0.35) | KDM4EHSD17B10TSHRNPSR1ALDH1A1 | |
| SCHEMBL8047602 | 0.61 | PDE5A (0.38) | — | |
| SCHEMBL8045595 | 0.61 | PDE5A (0.41) | PDE4BPDE7APDE9APDE1C | |
| SCHEMBL8042035 | 0.61 | — | — | |
| SCHEMBL8042668 | 0.60 | SLC2A1 (0.32) | — | |
| SCHEMBL8034133 | 0.60 | KDM4E (0.36) | KDM4EHSD17B10NPSR1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |