Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.55 |
| ▸ | TTR | P02766 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | DHFR | P00374 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ALB | P02768 | 1/20 | 0.54 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.54 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9842662 | 0.87 | ESR1 (0.66) | ESR1ESR2TTRKDM4EMEN1 | |
| SCHEMBL28226426 | 0.86 | ESR1 (0.70) | ESR1ESR2HSD17B10APPCYP2C19 | |
| SCHEMBL38659424 | 0.86 | ESR1 (0.70) | ESR1ESR2HSD17B10APPCYP2C19 | |
| SCHEMBL9057929 | 0.86 | ALDH1A1 (0.52) | ESR1ESR2TTRKDM4EMEN1 | |
| SCHEMBL9858166 | 0.84 | ESR1 (0.57) | ESR1ESR2MEN1KMT2AAPP | |
| SCHEMBL29901376 | 0.84 | ESR1 (0.57) | ESR1ESR2MEN1KMT2AAPP | |
| SCHEMBL29319763 | 0.83 | TTR (0.50) | ESR1ESR2TTRKDM4EMEN1 | |
| SCHEMBL22688379 | 0.82 | ESR1 (0.63) | ESR1ESR2TTRKDM4EMEN1 | |
| SCHEMBL27928527 | 0.81 | ESR1 (0.57) | ESR1ESR2APPCYP2C19CYP2C9 | |
| SCHEMBL28901881 | 0.81 | ESR1 (0.53) | ESR1ESR2APPCYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110078680-A | Isoxazoline benzamide compound and its preparation method and application | 山东大学 | 2019-08-02 | — | — | CN | claimed |
| EP-0367944-A2 | Ether derivative of 4-[3H] -quinazolinone, a process for the preparation thereof, and pharmaceutical compositions | SPOFA spojené podniky pro zdravotnickou vyrobu (CS) | 1990-05-16 | — | — | EP | claimed |
| EP-0080010-B1 | NOVEL COMPOUNDS WITH ANTIINFLAMMATORY AND ANALGESIC ACTIVITY, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS THEREFROM | AUSONIA FARMACEUTICI S.r.l. (IT) | 1985-08-07 | — | — | EP | claimed |
| US-4486599-A | Process for preparing the 2',4'-difluoro-4-hydroxy-(1,1'-diphenyl)-3-carboxylic acid | ZAMBON S.P.A. (IT) | 1984-12-04 | — | — | US | claimed |
| EP-0101625-A1 | Process for preparing the 2',4'-difluoro-4-hydroxy-(1,1'-diphenyl)-3-carboxylic acid | ZAMBON S.p.A. (IT) | 1984-02-29 | — | — | EP | claimed |
| EP-0080011-A1 | Novel compounds with antiinflammatory and analgesic activity, process for the preparation thereof and pharmaceutical compositions therefrom | AUSONIA FARMACEUTICI S.r.l. (IT) | 1983-06-01 | — | — | EP | claimed |
| EP-0080010-A1 | Novel compounds with antiinflammatory and analgesic activity, process for the preparation thereof and pharmaceutical compositions therefrom | AUSONIA FARMACEUTICI S.r.l. (IT) | 1983-06-01 | — | — | EP | claimed |
| EP-0033980-A1 | Derivatives of 2-methylpropionic acid, process for their preparation and pharmaceutical compositions containing them | SCHIAPPARELLI FARMACEUTICI S.p.A. (IT) | 1981-08-19 | — | — | EP | claimed |
| US-4225730-A | Process for preparing 4-(2,4-difluorophenyl)-salicyclic acid | MERCK & CO., INC. (US) | 1980-09-30 | — | — | US | claimed |
| US-20230219886-A1 | NOVEL SELENO-NSAID ANALOGS AND USES THEREOF | THE PENN STATE RESEARCH FOUNDATION | 2023-07-13 | — | — | US | disclosed |
| US-20220387345-A1 | ANTI-CANCER COMPOUNDS ACTING AS NON-PGP SUBSTRATE | ASCENTAWITS PHARMACEUTICALS, LTD. (CN) | 2022-12-08 | — | — | US | disclosed |
| US-20220119429-A1 | FLUORINE-CONTAINING COMPOUND AND ANTI-CANCER MEDICAL USE THEREOF | ASCENTAWITS PHARMACEUTICALS, LTD. (CN) | 2022-04-21 | — | — | US | disclosed |
| WO-2021083310-A1 | ANTI-CANCER COMPOUNDS ACTING AS NON-PGP SUBSTRATE | 深圳艾欣达伟医药科技有限公司 | 2021-05-06 | — | — | WO | disclosed |
| US-20210052748-A1 | NOVEL COMPOUND, ANTIINFLAMMATORY DRUG COMPRISING THE COMPOUND AND CYCLOOXYGENASE-2 INHIBITOR COMPRISING THE COMPOUND | CHANG, YONG MIN (KR) | 2021-02-25 | — | — | US | disclosed |
| EP-0080011-A1 | Novel compounds with antiinflammatory and analgesic activity, process for the preparation thereof and pharmaceutical compositions therefrom | AUSONIA FARMACEUTICI S.r.l. (IT) | 1983-06-01 | — | — | EP | disclosed |
| EP-0033980-A1 | Derivatives of 2-methylpropionic acid, process for their preparation and pharmaceutical compositions containing them | SCHIAPPARELLI FARMACEUTICI S.p.A. (IT) | 1981-08-19 | — | — | EP | disclosed |
| US-4225730-A | Process for preparing 4-(2,4-difluorophenyl)-salicyclic acid | MERCK & CO., INC. (US) | 1980-09-30 | — | — | US | disclosed |
| US-4225730-A | Process for preparing 4-(2,4-difluorophenyl)-salicyclic acid | MERCK & CO., INC. (US) | 1980-09-30 | — | — | US | disclosed |
| US-4044049-A | Phenyl benzoic acid compounds | MERCK & CO., INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-3992459-A | BIARYL COUPLING BY DIAZOTIZATION | MERCK & CO., INC. (US) | 1976-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210052748-A1 | NOVEL COMPOUND, ANTIINFLAMMATORY DRUG COMPRISING THE COMPOUND AND CYCLOOXYGENASE-2 INHIBITOR COMPRISING THE COMPOUND | PTGS2, PTGS1, PTGES2 | ESR1 3871/4885ESR2 920/4885TTR 4331/4885 |
| US-20220119429-A1 | FLUORINE-CONTAINING COMPOUND AND ANTI-CANCER MEDICAL USE THEREOF | FLI1, FOLR2, FOLR1 | ESR1 485/4885ESR2 303/4885TTR 4782/4885 |
| US-20220387345-A1 | ANTI-CANCER COMPOUNDS ACTING AS NON-PGP SUBSTRATE | ABCB1, ABCB11, IMPA1 | ESR1 1801/4885ESR2 3699/4885TTR 2527/4885 |
| US-20230219886-A1 | NOVEL SELENO-NSAID ANALOGS AND USES THEREOF | SELENOI, SCLY, GPX1 | ESR1 2235/4885ESR2 402/4885TTR 793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.