Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL411652 | 0.84 | KDM4C (0.34) | KDM4EALDH1A1MAOAMAOBACLY | |
| SCHEMBL411957 | 0.75 | CAMKK2 (0.35) | ALDH1A1MAOAMAOB | |
| SCHEMBL461118 | 0.72 | EGFR (0.52) | ALDH1A1 | |
| SCHEMBL412797 | 0.70 | ALDH1A1 (0.38) | KDM4EALDH1A1RAB9AMAOAMAOB | |
| SCHEMBL8138089 | 0.60 | TSHR (0.47) | KDM4EALDH1A1RAB9AMEN1TSHR | |
| SCHEMBL1950385 | 0.59 | CYP1A2 (0.50) | KDM4EALDH1A1MEN1TSHRKMT2A | |
| Acetic Acid SCHEMBL27291474 | 0.59 | MAOA (0.42) | ALDH1A1MAOAMAOBMEN1TSHR | |
| SCHEMBL8144583 | 0.58 | ACHE (0.52) | ALDH1A1MAOAMAOBMEN1KMT2A | |
| SCHEMBL217628 | 0.57 | TSHR (0.61) | KDM4EALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL32690872 | 0.57 | TSHR (0.61) | KDM4EALDH1A1MEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |