Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Propofol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 8/20 | 0.94 |
| ▸ | GABRB1 known ✓ | P18505 | 5/20 | 0.94 |
| ▸ | GABRB2 known ✓ | P47870 | 4/20 | 0.94 |
| ▸ | GABRG2 known ✓ | P18507 | 2/20 | 0.94 |
| ▸ | GABRB3 known ✓ | P28472 | 2/20 | 0.94 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.94 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.94 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.94 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.94 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.94 |
| ▸ | CA1 | P00915 | 2/20 | 0.94 |
| ▸ | CA2 | P00918 | 2/20 | 0.94 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.94 |
| ▸ | LMNA | P02545 | 2/20 | 0.94 |
| ▸ | FAAH | O00519 | 1/20 | 0.94 |
| ▸ | HPGD | P15428 | 1/20 | 0.94 |
| ▸ | TSHR | P16473 | 1/20 | 0.94 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.94 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propofol SCHEMBL5036811 | 1.00 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL36245 | 0.97 | GABRA1 (1.00) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL2414429 | 0.97 | GABRA1 (1.00) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL5087474 | 0.94 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL1033835 | 0.94 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL8935177 | 0.94 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL10968616 | 0.94 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL8026569 | 0.94 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL4088686 | 0.94 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL10968613 | 0.94 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113853290-A | Substantially flat-bottomed polymer vials and methods of injection stretch blow molding manufacture thereof | SIO2医药产品公司 | 2021-12-28 | — | — | CN | claimed |
| CN-109456360-B | Preparation method of fospropofol disodium | 河南中医药大学 | 2021-05-14 | — | — | CN | claimed |
| CN-106458823-A | Process for preparing unsaturated carboxylic acid salts | 巴斯夫欧洲公司 | 2017-02-22 | — | — | CN | claimed |
| CN-105753701-A | Double-effect anesthetic and preparation method and application thereof | 广东嘉博制药有限公司 | 2016-07-13 | — | — | CN | claimed |
| CN-114890987-B | Thiophenol-thiophene ligand and preparation method thereof, olefin polymerization catalyst and preparation method and application thereof | 万华化学集团股份有限公司 | 2023-12-19 | — | — | CN | disclosed |
| CN-113372198-B | Refining method of high-purity propofol | 山东威高药业股份有限公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-114601800-A | Methylphosphopropofol sodium sterile powder injection and preparation method thereof | 瑞普（天津）生物药业有限公司 | 2022-06-10 | — | — | CN | disclosed |
| CN-114414583-A | System and method for detecting syringe seal defects | W.L.戈尔及同仁股份有限公司 | 2022-04-29 | — | — | CN | disclosed |
| CN-107592807-B | Cycloolefin polymer container having a scratch-resistant and antistatic coating | SIO2医药产品公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-114307766-A | Concentration regulation formula anaesthesia device for department of anesthesia | 韩飞 | 2022-04-12 | — | — | CN | disclosed |
| CN-114129578-A | Application of fospropofol disodium in preparation of pet anesthesia and sedation drugs | 瑞普（天津）生物药业有限公司 | 2022-03-04 | — | — | CN | disclosed |
| CN-108474752-B | System and method for detecting syringe seal defects | W.L.戈尔及同仁股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-102552291-A | Vein medication preparation for fospropofol disodium, as well as preparation method and application of vein medication preparation | Shaanxi synthetic pharmaceutical co ltd | 2012-07-11 | — | — | CN | disclosed |
| CN-102397246-A | Fospropofol sodium for injection and preparation method and application thereof | SHANXI SYNTHETIC PHARMACEUTICAL CO LTD | 2012-04-04 | — | — | CN | disclosed |
| CN-102391137-A | Water-soluble amino acid ester derivative of propofol and application thereof | CHENGDU YIPING MEDICAL TECHNOLOGY DEV CO LTD | 2012-03-28 | — | — | CN | disclosed |
| CN-102085185-A | Formula and preparation method of novel propofol fat emulsion preparation causing no pain and low injection stimulation | XIAN LIBANG PHARMACEUTICAL CO LTD | 2011-06-08 | — | — | CN | disclosed |
| CN-101863918-A | Water-soluble dipropofol and preparation method thereof | SHIXI LI | 2010-10-20 | — | — | CN | disclosed |
| US-20090131538-A1 | Novel propofol composition comprising a pharmaceutically acceptable salt of formaldehyde sulfoxylate | Taro Pharmaceuticals North America, Inc. c/o Taro Pharmaceuticals U.S.A., Inc. (US) | 2009-05-21 | — | — | US | disclosed |
| CN-1195783-C | Polymerization of olefins | DU PONT (US) | 2005-04-06 | — | — | CN | disclosed |
| CN-1320130-A | Polymerization of olefins | DU PONT (US) | 2001-10-31 | — | — | CN | disclosed |