Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.57 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.57 |
| ▸ | F2R | P25116 | 1/20 | 0.55 |
| ▸ | CCR5 | P51681 | 4/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830370 | 1.00 | SMN1; SMN2 (0.63) | SMN1; SMN2RECQLLMNAITGB3ITGA2B | |
| SCHEMBL4696189 | 0.97 | SMN1; SMN2 (0.67) | SMN1; SMN2RECQLLMNAITGB3ITGA2B | |
| SCHEMBL4696193 | 0.97 | SMN1; SMN2 (0.67) | SMN1; SMN2RECQLLMNAITGB3ITGA2B | |
| Formic Acid SCHEMBL27557118 | 0.94 | SMN1; SMN2 (0.58) | SMN1; SMN2RECQLLMNAITGB3ITGA2B | |
| SCHEMBL9829153 | 0.94 | ITGB3 (0.59) | SMN1; SMN2RECQLLMNAITGB3ITGA2B | |
| SCHEMBL4130312 | 0.88 | RECQL (0.62) | SMN1; SMN2RECQLLMNACCR5KCNH2 | |
| SCHEMBL1573959 | 0.86 | RECQL (0.59) | SMN1; SMN2RECQLLMNAITGB3ITGA2B | |
| SCHEMBL1573757 | 0.86 | RECQL (0.59) | SMN1; SMN2RECQLLMNAITGB3ITGA2B | |
| SCHEMBL5424938 | 0.85 | LMNA (0.61) | SMN1; SMN2RECQLLMNACCR5KCNH2 | |
| SCHEMBL7113507 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2RECQLLMNAITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090209578-A1 | CHEMICAL COMPOUNDS | PFIZER INC | 2009-08-20 | — | — | US | disclosed |
| US-6586430-B1 | Administering azabicyclo compounds to treat human immunodeficiency virus infections and respiratory system disorders | PFIZER INC. | 2003-07-01 | — | — | US | disclosed |
| US-6511994-B2 | For prophylaxis and therapy of infection by HIV and the treatment of AIDS | MERCK & CO., INC. | 2003-01-28 | — | — | US | disclosed |
| US-20020193407-A1 | Modulators of CCR5 chemokine receptor activity | MERCK SHARP & DOHME CORP. | 2002-12-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193407-A1 | Modulators of CCR5 chemokine receptor activity | CCR5, CXCR3, CXCR1 | SMN1; SMN2 4601/4885RECQL 317/4885LMNA 4615/4885 |
| US-20090209578-A1 | CHEMICAL COMPOUNDS | CCR5, CXCR3, CXCR1 | SMN1; SMN2 4870/4885RECQL 1937/4885LMNA 4759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.