SCHEMBL4139519

SCHEMBL4139519

Cc1ccc(S(=O)(=O)S(C)(=O)=O)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.59
CA1 P00915 3/20 0.54
CA2 P00918 3/20 0.54
CA12 O43570 1/20 0.54
CA3 P07451 1/20 0.54
CA6 P23280 1/20 0.54
CA5A P35218 1/20 0.54
CA7 P43166 1/20 0.54
CA9 Q16790 1/20 0.54
CA5B Q9Y2D0 1/20 0.54
TLR9 Q9NR96 1/20 0.52
SMN1; SMN2 Q16637 2/20 0.50
ALDH1A1 P00352 4/20 0.48
CYP3A4 P08684 2/20 0.48
CYP2C9 P11712 2/20 0.48
CYP2C19 P33261 2/20 0.48
MMP1 P03956 1/20 0.48
MMP2 P08253 1/20 0.48
MMP9 P14780 1/20 0.48
MMP8 P22894 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8038985 0.86 GAA (0.68) GAACA1CA2CA12CA3
SCHEMBL547554 0.86 GAA (0.68) GAACA1CA2CA12CA3
SCHEMBL1060443 0.81 GAA (0.62) GAACA1CA2CA12CA3
SCHEMBL28449841 0.81 GAA (0.62) GAACA1CA2CA12CA3
SCHEMBL1332797 0.79 GAA (0.59) GAACA1CA2CA12CA3
SCHEMBL664115 0.79 GAA (0.59) GAACA1CA2CA12CA3
SCHEMBL12807 0.78 GAA (0.65) GAACA1CA2CA12CA3
SCHEMBL28182477 0.78 GAA (0.65) GAACA1CA2CA12CA3
SCHEMBL11586425 0.77 GAA (0.56) GAACA1CA2CA12CA3
SCHEMBL9142919 0.77 GAA (0.56) GAACA1CA2CA12CA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011158248-A2 PROCESS FOR PREPARATION OF POSACONAZOLE AND CRYSTALLINE POLYMORPHIC FORM V OF POSACONAZOLE GLENMARK GENERICS LIMITED (IN) 2011-12-22 WO claimed
US-20240160213-A1 MAP DATA GENERATION DEVICE, STORAGE MEDIUM, AND MAP DATA GENERATION METHOD CANON KABUSHIKI KAISHA (JP) 2024-05-16 US disclosed
US-11925690-B2 Bifunctional molecules for targeting Rpn11 AMPHISTA THERAPEUTICS LIMITED (GB) 2024-03-12 US disclosed
CN-115368340-B Oxime sulfonate photoacid generator, resist composition containing oxime sulfonate photoacid generator, electronic device and application of oxime sulfonate photoacid generator 常州强力先端电子材料有限公司 2024-01-26 CN disclosed
CN-115368341-B Oxime sulfonate compound, resist composition containing oxime sulfonate compound, electronic device and application of oxime sulfonate compound 常州强力先端电子材料有限公司 2024-01-26 CN disclosed
US-20210283139-A1 BIFUNCTIONAL MOLECULES FOR TARGETING UCHL5 AMPHISTA THERAPEUTICS LIMITED (GB) 2021-09-16 US disclosed
EP-3807272-A1 BIFUNCTIONAL MOLECULES FOR TARGETING RPN11 Amphista Therapeutics Ltd (GB) 2021-04-21 EP disclosed
EP-3807263-A1 BIFUNCTIONAL MOLECULES FOR TARGETING UCHL5 Amphista Therapeutics Ltd (GB) 2021-04-21 EP disclosed
WO-2019238886-A1 BIFUNCTIONAL MOLECULES FOR TARGETING USP14 UNIVERSITY OF DUNDEE (GB) 2019-12-19 WO disclosed
WO-2019238817-A1 BIFUNCTIONAL MOLECULES FOR TARGETING RPN11 UNIVERSITY OF DUNDEE (GB) 2019-12-19 WO disclosed
WO-2019238816-A1 BIFUNCTIONAL MOLECULES FOR TARGETING UCHL5 UNIVERSITY OF DUNDEE (GB) 2019-12-19 WO disclosed
US-9765019-B2 Small-molecule-targeted protein degradation BRANDEIS UNIVERSITY (US) 2017-09-19 US disclosed
US-9408928-B2 Compositions for targeted imaging and therapy Radiomedix, Inc. (US) 2016-08-09 US disclosed
CN-101516899-B Compositions and methods for cellular imaging and therapy 得克萨斯大学体系董事会 2016-07-06 CN disclosed
US-20130190340-A1 Small-Molecule-Targeted Protein Degradation BRANDEIS UNIVERSITY (US) 2013-07-25 US disclosed
US-8188287-B2 Piperidyl acrylamide antagonists of CCR2 JANSSEN PHARMACEUTICA N.V. (BE) 2012-05-29 US disclosed
US-20090087377-A1 COMPOSITIONS FOR TARGETED IMAGING AND THERAPY THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMY 2009-04-02 US disclosed
EP-0210804-B1 PHOSPHATE ESTER DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE SANKYO COMPANY LIMITED (JP) 1989-05-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090087377-A1 COMPOSITIONS FOR TARGETED IMAGING AND THERAPY EGFR, ASGR1, TK1 GAA 193/4885CA1 916/4885CA2 2784/4885
US-20210283139-A1 BIFUNCTIONAL MOLECULES FOR TARGETING UCHL5 UCHL5, UCHL3, UCHL1 GAA 1008/4885CA1 4039/4885CA2 4667/4885
US-20130190340-A1 Small-Molecule-Targeted Protein Degradation SMURF2, SMURF1, MDM2 GAA 260/4885CA1 4084/4885CA2 4400/4885
US-11925690-B2 Bifunctional molecules for targeting Rpn11 RPN1, RPP30, UBQLN1 GAA 1165/4885CA1 4816/4885CA2 4719/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.