Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.53 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3355855 | 1.00 | PTGS2 (0.57) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL4486188 | 0.91 | AKR1C3 (0.50) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL8522917 | 0.90 | PTGS1 (0.55) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL13668901 | 0.88 | PTGS1 (0.53) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL2998970 | 0.88 | PTGS1 (0.47) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL1122739 | 0.86 | BCL2 (0.64) | PTGS2PTGS1MAPTALDH1A1LMNA | |
| SCHEMBL8576518 | 0.86 | PTGS1 (0.55) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL8523457 | 0.86 | PTGS1 (0.55) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL7038218 | 0.86 | MAPT (0.50) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL8462914 | 0.85 | PTGS1 (0.50) | PTGS2PTGS1MAPTCXCR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090170934-A1 | MANUFACTURING PROCESS FOR NO-DONATING COMPOUNDS SUCH AS NO-DONATING DICLOFENAC | NICOX SA | 2009-07-02 | — | — | US | disclosed |
| US-20090096314-A1 | ELECTRIC MOTOR | HONDA MOTOR CO., LTD. (JP) | 2009-04-16 | — | — | US | disclosed |
| US-20060122402-A1 | Manufacturing process for no-donating compounds such as no-donating diclofenac | NICOX SA (FR) | 2006-06-08 | — | — | US | disclosed |
| CN-1684940-A | Manufacturing process for NO-donating compounds such as NO-donating diclofenac | NICOX SA (FR) | 2005-10-19 | — | — | CN | disclosed |
| EP-1558559-A1 | MANUFACTURING PROCESS FOR NO-DONATING COMPOUNDS SUCH AS NO-DONATING DICLOFENAC | Nicox S.A. (FR) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004026808-A1 | MANUFACTURING PROCESS FOR NO-DONATING COMPOUNDS SUCH AS NO-DONATING DICLOFENAC | NICOX SA. (FR) | 2004-04-01 | — | — | WO | disclosed |
| US-20030049807-A1 | Micro-organism possessing enantioselective and regioselective nitrile hydratase/amidase activities | INSTITUTO BIOCHIMICO ITALIANO GIOVANNI LOREZINI S.P.A. (IT) | 2003-03-13 | — | — | US | disclosed |
| EP-1291435-A2 | A micro-organism possessing enantioselective and regioselective nitrile hydratase/amidase activities | ISTITUTO BIOCHIMICO ITALIANO GIOVANNI LORENZINI S.p.A. (IT) | 2003-03-12 | — | — | EP | disclosed |
| US-4465855-A | ANTIREUMATIC & ANTIINFLAMMATORIES | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT (HU) | 1984-08-14 | — | — | US | disclosed |
| US-4385004-A | Esters of ortho-allylphenol useful for the preparation of arylacetic acid derivatives | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1983-05-24 | — | — | US | disclosed |
| US-4317920-A | ANTIRHEUMATIC AGENTS, ANTIINFLAMMATORY AGENTS | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1982-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122402-A1 | Manufacturing process for no-donating compounds such as no-donating diclofenac | NOS2, NOS1, NOS3 | PTGS2 30/4885PTGS1 28/4885MAPT 3503/4885 |
| US-20090170934-A1 | MANUFACTURING PROCESS FOR NO-DONATING COMPOUNDS SUCH AS NO-DONATING DICLOFENAC | NOS2, NOS1, NOS3 | PTGS2 30/4885PTGS1 28/4885MAPT 3503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.