Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 4/20 | 1.00 |
| ▸ | PTGES | O14684 | 1/20 | 0.72 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.72 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9458992 | 0.85 | ALOX5 (0.86) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| Licofelone SCHEMBL237833 | 0.84 | ALOX5 (1.00) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL12203023 | 0.80 | ALOX5 (0.81) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| Licofelone SCHEMBL1843506 | 0.80 | PTGES (0.92) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL18782756 | 0.79 | ALOX5 (0.79) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| Licofelone SCHEMBL1394262 | 0.79 | PTGES (0.84) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| Licofelone SCHEMBL7737421 | 0.78 | PTGES (0.88) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL13653074 | 0.77 | PTGES (0.82) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL5560426 | 0.76 | PTGES (0.85) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL13697422 | 0.76 | PTGES (0.85) | ALOX5PTGS1PTGESALOX5APPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221697-A1 | MACROLIDE CONJUGATES OF PYRROLIZINE AND INDOLIZINE COMPOUNDS AS INHIBITORS OF 5-LIPOOXYGENASE AND CYCLOOXYGENASE | MERCKLE GMBH (DE) | 2009-09-03 | — | — | US | disclosed |
| CN-101228171-A | Macrolide conjugates of pyrrolizine and indolizine compounds as inhibitors of 5-lipooxygenase and cyclooxygenase | MERCKLE GMBH (DE) | 2008-07-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221697-A1 | MACROLIDE CONJUGATES OF PYRROLIZINE AND INDOLIZINE COMPOUNDS AS INHIBITORS OF 5-LIPOOXYGENASE AND CYCLOOXYGENASE | ALOX5, ALOX15, ALOX15B | ALOX5 1/4885PTGS1 12/4885PTGES 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.