Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTO1 | P78417 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | BMP1 | P13497 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | CCKAR | P32238 | 1/20 | 0.35 |
| ▸ | SGK1 | O00141 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4134999 | 0.91 | GSTO1 (0.44) | GSTO1ALDH1A1CCR1POLBL3MBTL1 | |
| SCHEMBL4148564 | 0.88 | CCR1 (0.40) | GSTO1SMN1; SMN2USP2ALDH1A1CCR1 | |
| SCHEMBL4131370 | 0.87 | CNR2 (0.49) | GSTO1SMN1; SMN2USP2ALDH1A1POLB | |
| SCHEMBL4148627 | 0.82 | BMP1 (0.37) | GSTO1SMN1; SMN2USP2ALDH1A1CCR1 | |
| SCHEMBL4148621 | 0.82 | BMP1 (0.37) | GSTO1SMN1; SMN2USP2ALDH1A1CCR1 | |
| SCHEMBL4136813 | 0.80 | TRPV4 (0.40) | GSTO1ALDH1A1CCR1L3MBTL1TRPV4 | |
| SCHEMBL4135951 | 0.79 | TRPV4 (0.38) | CCR1TRPV4GAAHPGD | |
| SCHEMBL4130838 | 0.79 | TRPV4 (0.37) | GSTO1CCR1TRPV4CNR2GAA | |
| SCHEMBL4134996 | 0.78 | GAA (0.40) | GSTO1SMN1; SMN2CCR1L3MBTL1TRPV4 | |
| SCHEMBL4145503 | 0.78 | PTGES (0.41) | L3MBTL1TRPV4GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | SMITHKLINE BEECHAM CORPORATION | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | TRPV4, TRPC4, TRPV1 | GSTO1 4156/4885SMN1; SMN2 2937/4885USP2 4586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.