Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971923 | 0.82 | CHRM5 (0.47) | CYP1A2CYP3A4CYP2D6MEN1CYP2C9 | |
| SCHEMBL8435518 | 0.77 | CYP1A1 (0.54) | CYP1A2CYP3A4CYP2D6DAPK3NPSR1 | |
| SCHEMBL8438601 | 0.76 | CHRM5 (0.42) | CYP1A2CYP3A4CYP2D6MEN1CYP2C9 | |
| SCHEMBL3300271 | 0.74 | CHRM5 (0.62) | CYP1A2CYP2D6MEN1CYP2C9CYP2C19 | |
| SCHEMBL7968716 | 0.73 | POLB (0.41) | CYP1A2CYP3A4CYP2D6MEN1CYP2C9 | |
| SCHEMBL550283 | 0.70 | NOTUM (0.54) | FLT3KDRMAPTGRM2GSK3B | |
| SCHEMBL7958570 | 0.70 | CYP11B2 (0.46) | MAPK1CYP1A2CYP3A4CYP2D6DAPK3 | |
| SCHEMBL7969830 | 0.70 | TP53 (0.43) | CYP1A2CYP3A4MEN1CYP2C9CYP2C19 | |
| SCHEMBL4162173 | 0.70 | XDH (0.58) | PDGFRBPDGFRAMEN1KMT2AKDR | |
| SCHEMBL6268358 | 0.70 | MAPT (0.61) | CYP1A2CYP3A4CYP2D6MEN1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | BIOFOCUS DISCOVERY LTD. | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | ROCK1, ROCK2, CIT | MAPK1 382/4885PDGFRB 1244/4885PDGFRA 1484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.