Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.51 |
| ▸ | SGK1 | O00141 | 7/20 | 0.44 |
| ▸ | AXL | P30530 | 6/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4168451 | 0.81 | SGK1 (0.41) | SGK1AXLCAMKK2CDK8ABL1 | |
| SCHEMBL4157425 | 0.78 | RIPK1 (0.52) | AXLCDK8ABL1MAP4K1DYRK1A | |
| SCHEMBL4154994 | 0.74 | AXL (0.45) | MAP3K11SGK1AXLCAMKK2CDK8 | |
| SCHEMBL30116111 | 0.72 | AAK1 (0.41) | MAP3K11SGK1AXLCAMKK2CDK8 | |
| SCHEMBL23753439 | 0.72 | RXRA (0.43) | — | |
| SCHEMBL29034266 | 0.71 | GBA1 (0.46) | — | |
| SCHEMBL4159593 | 0.71 | AXL (0.69) | MAP3K11SGK1AXLCAMKK2CDK8 | |
| SCHEMBL8321012 | 0.71 | MAPK8 (0.63) | MAP3K11SGK1AXLCDK8CLK1 | |
| Bromide SCHEMBL4164915 | 0.70 | AXL (0.67) | MAP3K11SGK1AXLCAMKK2CDK8 | |
| SCHEMBL5549486 | 0.69 | CDK8 (0.42) | SGK1AXLCAMKK2CDK8CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | GLAXOSMITHKLINE LLC | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | SGK1, SGK2, SGK3 | MAP3K11 56/4885SGK1 1/4885AXL 1542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.