Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.52 |
| ▸ | CDK8 | P49336 | 9/20 | 0.50 |
| ▸ | CDK7 | P50613 | 2/20 | 0.50 |
| ▸ | PLK4 | O00444 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | INSR | P06213 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | ROS1 | P08922 | 2/20 | 0.50 |
| ▸ | FER | P16591 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | MARK3 | P27448 | 2/20 | 0.50 |
| ▸ | FLT4 | P35916 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | SYK | P43405 | 2/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.50 |
| ▸ | CLK2 | P49760 | 2/20 | 0.50 |
| ▸ | BLK | P51451 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4160322 | 0.79 | CDK8 (0.46) | RIPK1CDK8CDK7PLK4ROCK2 | |
| SCHEMBL4154787 | 0.78 | MAP3K11 (0.51) | CDK8AXLMAP4K1DYRK1BABL1 | |
| SCHEMBL23753439 | 0.74 | RXRA (0.43) | MAP4K4CSNK2A1MKNK2PDGFRBPDGFRA | |
| SCHEMBL4831501 | 0.72 | CDK8 (0.81) | RIPK1CDK8CDK7PLK4ROCK2 | |
| SCHEMBL4167250 | 0.72 | RIPK1 (0.59) | RIPK1CDK8CDK7PLK4ROCK2 | |
| SCHEMBL29652419 | 0.71 | RIPK1 (0.66) | RIPK1CDK8CDK7PLK4ROCK2 | |
| SCHEMBL298331 | 0.71 | CDK8 (0.67) | RIPK1CDK8CDK7PLK4ROCK2 | |
| SCHEMBL14365347 | 0.71 | RIPK1 (0.65) | RIPK1CDK8CDK7PLK4ROCK2 | |
| SCHEMBL858525 | 0.69 | RIPK1 (1.00) | RIPK1CDK8CDK7PLK4ROCK2 | |
| SCHEMBL4923675 | 0.69 | RAB9A (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | GLAXOSMITHKLINE LLC | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | SGK1, SGK2, SGK3 | RIPK1 143/4885CDK8 525/4885CDK7 401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.