Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 7/20 | 0.41 |
| ▸ | AXL | P30530 | 9/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.36 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.36 |
| ▸ | INSR | P06213 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | FES | P07332 | 2/20 | 0.36 |
| ▸ | ROS1 | P08922 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.36 |
| ▸ | FER | P16591 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | MARK3 | P27448 | 2/20 | 0.36 |
| ▸ | FLT4 | P35916 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4160322 | 0.83 | CDK8 (0.46) | AXLPLK4ROCK2PRKD3INSR | |
| SCHEMBL4154787 | 0.81 | MAP3K11 (0.51) | SGK1AXLCAMKK2DYRK1ACDK8 | |
| SCHEMBL4154983 | 0.73 | TRPM8 (0.41) | — | |
| SCHEMBL4159593 | 0.68 | AXL (0.69) | SGK1AXLCAMKK2PLK4AURKA | |
| Bromide SCHEMBL4164915 | 0.67 | AXL (0.67) | SGK1AXLCAMKK2PLK4AURKA | |
| SCHEMBL13854133 | 0.67 | CDK2 (0.63) | SGK1AXLPLK4AURKAROCK2 | |
| SCHEMBL27677221 | 0.66 | CYP1A2 (0.41) | FLT3PDPK1CSF1R | |
| SCHEMBL4154994 | 0.62 | AXL (0.45) | SGK1AXLCAMKK2DYRK1ACDK8 | |
| SCHEMBL4157425 | 0.62 | RIPK1 (0.52) | AXLPLK4ROCK2PRKD3INSR | |
| SCHEMBL8321012 | 0.61 | MAPK8 (0.63) | SGK1AXLMAPK8DYRK1ACDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | GlaxoSmithKline, LLC | 2012-09-20 | — | — | US | disclosed |
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | GLAXOSMITHKLINE LLC | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | SGK1, SGK2, SGK3 | SGK1 1/4885AXL 1542/4885CAMKK2 157/4885 |
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | SGK1, SGK2, SGK3 | SGK1 1/4885AXL 1432/4885CAMKK2 125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.