SCHEMBL4155639

SCHEMBL4155639

Cc1cccc(C=Cc2ccccc2)c1-c1ccccn1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.41
MAPT P10636 2/20 0.41
GRM4 Q14833 2/20 0.41
KDM1A O60341 3/20 0.41
KDM4E B2RXH2 3/20 0.41
APOBEC3G Q9HC16 2/20 0.41
RAB9A P51151 2/20 0.41
APOBEC3A P31941 1/20 0.41
NFE2L2 Q16236 3/20 0.40
TRPA1 O75762 2/20 0.40
SIGMAR1 Q99720 1/20 0.40
LMNA P02545 2/20 0.40
NPC1 O15118 1/20 0.40
PKM P14618 1/20 0.40
CHAT P28329 1/20 0.40
CYP1A2 P05177 1/20 0.39
POLB P06746 1/20 0.39
CCR1 P32246 1/20 0.39
CCR5 P51681 1/20 0.39
CCR8 P51685 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4155634 1.00 L3MBTL1 (0.41) L3MBTL1MAPTGRM4KDM1AKDM4E
SCHEMBL4165025 0.89 KDM4E (0.46) L3MBTL1MAPTKDM1AKDM4ERAB9A
SCHEMBL4165023 0.89 KDM4E (0.46) L3MBTL1MAPTKDM1AKDM4ERAB9A
SCHEMBL28565356 0.84 KDM1A (0.48) L3MBTL1MAPTKDM1AKDM4ERAB9A
SCHEMBL4151183 0.83 ALDH1A1 (0.53) L3MBTL1MAPTGRM4KDM4EAPOBEC3G
SCHEMBL4151179 0.83 ALDH1A1 (0.53) L3MBTL1MAPTGRM4KDM4EAPOBEC3G
SCHEMBL4159062 0.81 NFE2L2 (0.59) L3MBTL1MAPTKDM4EAPOBEC3GRAB9A
SCHEMBL4159067 0.81 NFE2L2 (0.59) L3MBTL1MAPTKDM4EAPOBEC3GRAB9A
SCHEMBL28564889 0.79 KDM4E (0.43) L3MBTL1MAPTKDM4EAPOBEC3GRAB9A
SCHEMBL20578701 0.79 TSHR (0.52) L3MBTL1KDM4EAPOBEC3GRAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8212048-B2 Method of producing aromatic compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-07-03 US disclosed
CN-101410375-B Process for producing aromatic compound SUMITOMO CO LTD 2012-06-13 CN disclosed
CN-101410375-A Process for producing aromatic compound SUMITOMO CHEMICAL CO (JP) 2009-04-15 CN disclosed
US-20090043096-A1 METHOD OF PRODUCING AROMATIC COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-02-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090043096-A1 METHOD OF PRODUCING AROMATIC COMPOUND AHR, CYP1A1, ARNT L3MBTL1 3903/4885MAPT 2834/4885GRM4 3472/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.