SCHEMBL4156586

SCHEMBL4156586

CCc1cccc(O)c1-c1cc[nH]n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 2/20 0.42
GABRA1 P14867 2/20 0.41
GABRB2 P47870 2/20 0.41
ANPEP P15144 1/20 0.40
DPP4 P27487 1/20 0.40
DDO Q99489 1/20 0.39
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA7 P43166 1/20 0.35
CA9 Q16790 1/20 0.35
CA14 Q9ULX7 1/20 0.35
IAPP P10997 3/20 0.34
APP P05067 3/20 0.34
HSP90AA1 P07900 1/20 0.34
HTR1A P08908 1/20 0.33
TAAR1 Q96RJ0 1/20 0.33
ELANE P08246 1/20 0.33
CTSG P08311 1/20 0.33
ITGA2 P17301 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23923799 0.82 APP (0.40) DAOCA12CA1CA2CA14
SCHEMBL3344675 0.76 GABRA1 (0.61) DAOGABRA1GABRB2ANPEPDPP4
SCHEMBL31005224 0.75 HSP90AA1 (0.45) DAOAPPHSP90AA1
SCHEMBL11019413 0.74 GABRA1 (0.58) DAOGABRA1GABRB2ANPEPDPP4
SCHEMBL4156587 0.74 ALDH1A1 (0.33) DAOANPEPDPP4CA12CA1
SCHEMBL11620477 0.73 TRPA1 (0.39) GABRA1GABRB2HTR1ATAAR1
SCHEMBL13675152 0.71 HSD17B1 (0.47) DAOGABRA1GABRB2CA12CA9
SCHEMBL5527504 0.71 APP (0.33) CA1CA2APP
SCHEMBL21375829 0.70 ADRA2A (0.34) DAOGABRA1GABRB2HTR1ATAAR1
SCHEMBL4096433 0.69 HSD17B1 (0.53) GABRA1GABRB2CA12CA9HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2044063-A1 PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER Astra Zeneca AB (SE) 2009-04-08 EP disclosed
WO-2008001070-A1 PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER ASTRAZENECA AB (SE) 2008-01-03 WO disclosed