Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 6/20 | 0.61 |
| ▸ | BCHE | P06276 | 3/20 | 0.61 |
| ▸ | TGM2 | P21980 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.58 |
| ▸ | ALDH3A1 | P30838 | 6/20 | 0.58 |
| ▸ | ALDH2 | P05091 | 4/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.58 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4159335 | 0.84 | HPGD (0.57) | CES1BCHETGM2ALDH1A1ALDH3A1 | |
| SCHEMBL12930188 | 0.84 | ALDH1A1 (0.71) | CES1BCHETGM2ALDH1A1ALDH3A1 | |
| SCHEMBL9770647 | 0.80 | RAB9A (0.66) | ALDH1A1PKMMAPTLMNAKMT2A | |
| SCHEMBL3331215 | 0.79 | CES1 (0.65) | CES1BCHETGM2ALDH1A1ALDH3A1 | |
| SCHEMBL25339731 | 0.77 | MAPT (0.41) | CES1BCHETGM2ALDH1A1ALDH3A1 | |
| SCHEMBL6258757 | 0.77 | CES1 (0.71) | CES1BCHETGM2ALDH1A1ALDH3A1 | |
| SCHEMBL8764222 | 0.76 | MGLL (0.52) | MAPTMAPK1 | |
| SCHEMBL19924204 | 0.76 | CES1 (1.00) | CES1BCHETGM2ALDH1A1ALDH3A1 | |
| SCHEMBL29506660 | 0.74 | ALDH1A1 (1.00) | CES1BCHETGM2ALDH1A1ALDH3A1 | |
| SCHEMBL2087729 | 0.74 | ALDH1A1 (1.00) | CES1BCHETGM2ALDH1A1ALDH3A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329686-B2 | Isatin analogues and uses therefor | WASHINGTON UNIVERSITY (US) | 2012-12-11 | — | — | US | disclosed |
| US-20090068105-A1 | ISATIN ANALOGUES AND USES THEREFOR | WASHINGTON UNIVERSITY IN ST. LOUIS | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090068105-A1 | ISATIN ANALOGUES AND USES THEREFOR | CASP7, CASP3, HASPIN | CES1 1158/4885BCHE 745/4885TGM2 2896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.