SCHEMBL4164063

SCHEMBL4164063

CS(=O)(=O)c1ncc(Cl)s1

nearest known ligand 0.32

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA4 P22748 1/20 0.32
CA5A P35218 1/20 0.32
CA5B Q9Y2D0 1/20 0.32
KMT2A Q03164 1/20 0.32
ALOX15 P16050 1/20 0.32
PSEN1 P49768 1/20 0.32
PSEN2 P49810 1/20 0.32
APH1B Q8WW43 1/20 0.32
NCSTN Q92542 1/20 0.32
APH1A Q96BI3 1/20 0.32
PSENEN Q9NZ42 1/20 0.32
PIP4K2A P48426 1/20 0.31
LOX P28300 1/20 0.30
LOXL2 Q9Y4K0 1/20 0.30
KDR P35968 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2702752 0.80 ALOX15 (0.33) ALOX15PSEN1PSEN2APH1BNCSTN
SCHEMBL1548616 0.78 CA2 (0.39) CA1CA2CA4CA5ACA5B
SCHEMBL3439198 0.76 NOS1 (0.43) CA1CA2CA4CA5ACA5B
SCHEMBL2885927 0.74 FBP1 (0.35) CA1CA2CA4CA5ACA5B
SCHEMBL7993752 0.74 LOXL2 (0.34) CA1CA2CA4CA5ACA5B
SCHEMBL24667434 0.69 HCAR2 (0.55) KMT2A
SCHEMBL4171168 0.69 CA1 (0.30) CA1CA2CA4CA5ACA5B
SCHEMBL3123975 0.69 LOXL2 (0.50) LOXLOXL2
SCHEMBL9826897 0.69 MEN1 (0.37) KMT2APIP4K2ALOXLOXL2KDR
SCHEMBL18827776 0.69 LOXL2 (0.32) PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200060276-A1 THIAZOLE COMPOUND AND HERBICIDE OAT AGRIO CO., LTD. (JP) 2020-02-27 US disclosed
US-20200060276-A1 THIAZOLE COMPOUND AND HERBICIDE OAT AGRIO CO., LTD. (JP) 2020-02-27 US disclosed
US-20090048112-A1 Novel Herbicides SYNGENTA LIMITED (GB) 2009-02-19 US disclosed
US-20090048112-A1 Novel Herbicides SYNGENTA LIMITED (GB) 2009-02-19 US disclosed
US-20090048112-A1 Novel Herbicides SYNGENTA LIMITED (GB) 2009-02-19 US disclosed
EP-1885720-A2 4-(THIAZOL-2-YLTHIOALKYL)-PYRAZOLES AND THEIR USE AS HERBICIDES Syngenta Limited (GB) 2008-02-13 EP disclosed
WO-2006123088-A2 4- (THIAZOL-2-YLTHIOALKYL) -PYRAZOLES AND THEIR USE AS HERBICIDES SYNGENTA LIMITED (GB) 2006-11-23 WO disclosed
EP-0075840-B1 HETEROCYCLIC PHENYL ETHERS, PROCESS FOR THEIR PREPARATION AND HERBICIDES CONTAINING THEM HOECHST AKTIENGESELLSCHAFT (DE) 1987-11-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200060276-A1 THIAZOLE COMPOUND AND HERBICIDE OR10J3, OXSR1, OXER1 CA1 1575/4885CA2 631/4885CA4 327/4885
US-20090048112-A1 Novel Herbicides HAX1, MTX1, CYP4X1 CA1 1084/4885CA2 668/4885CA4 1338/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.