Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KHK | P50053 | 1/20 | 0.33 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4161023 | 0.84 | HRH3 (0.52) | HRH3KCNH2 | |
| SCHEMBL4013186 | 0.82 | SLC6A4 (0.37) | SLC6A4SLC6A2SLC6A3MAPTRXFP1 | |
| SCHEMBL1813625 | 0.82 | SLC6A4 (0.37) | SLC6A4SLC6A2SLC6A3MAPTRXFP1 | |
| SCHEMBL1814722 | 0.80 | KHK (0.44) | SLC6A4SLC6A2SLC6A3HPGDKHK | |
| SCHEMBL2884746 | 0.76 | HRH3 (0.51) | HDAC1HDAC8HDAC6HRH3KMT2A | |
| SCHEMBL4169878 | 0.75 | MGLL (0.42) | MAPTMEN1KMT2AHPGDKCNH2 | |
| SCHEMBL4167473 | 0.75 | MGLL (0.35) | SLC6A4SLC6A2SLC6A3HDAC1HDAC8 | |
| SCHEMBL4166486 | 0.75 | KDM2B (0.40) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4764592 | 0.75 | HRH3 (0.54) | HDAC1HDAC6HRH3KCNH2CYP2D6 | |
| SCHEMBL3841290 | 0.74 | ALDH1A1 (0.47) | SLC6A4SLC6A2ALDH1A1KDM2BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074088-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008045371-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-04-17 | — | — | WO | claimed |