Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 3/20 | 0.54 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.54 |
| ▸ | SCD5 | Q86SK9 | 7/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SCD | O00767 | 2/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4178010 | 0.84 | TRPC3 (0.51) | TRPC3TRPC6ALDH1A1HPGD | |
| SCHEMBL4176363 | 0.83 | TACR3 (0.47) | TRPC3TRPC6SCD5SCDALDH1A1 | |
| SCHEMBL4178403 | 0.82 | TRPC3 (0.41) | TRPC3TRPC6RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4180139 | 0.82 | ALDH1A1 (0.47) | TRPC3TRPC6RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4167596 | 0.82 | TRPC3 (0.44) | TRPC3TRPC6RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4178123 | 0.82 | SPR (0.45) | TRPC3TRPC6RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4178536 | 0.82 | TRPC3 (0.42) | TRPC3TRPC6SCD5RAB9ANPC1 | |
| SCHEMBL4172599 | 0.82 | TRPC3 (0.61) | TRPC3TRPC6SCD5SCDSCN9A | |
| SCHEMBL4165105 | 0.81 | TRPC3 (0.66) | TRPC3TRPC6SCD5SMN1; SMN2MAPT | |
| SCHEMBL4171049 | 0.80 | ALDH1A1 (0.43) | RAB9ANPC1SMN1; SMN2MAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357711-B2 | Heterocyclic sulfonamides as inhibitors of ion channels | PFIZER LIMITED (GB) | 2013-01-22 | — | — | US | disclosed |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPV5, TRPA1 | TRPC3 57/4885TRPC6 84/4885SCD5 1301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.