Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TRPC3 | Q13507 | 5/20 | 0.41 |
| ▸ | TRPC6 | Q9Y210 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4176363 | 0.91 | TACR3 (0.47) | SPRMEN1KMT2ATRPC3TRPC6 | |
| SCHEMBL4167596 | 0.85 | TRPC3 (0.44) | MEN1KMT2ATRPC3TRPC6ALDH1A1 | |
| SCHEMBL4172610 | 0.82 | SCD5 (0.41) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL4178167 | 0.82 | TRPC3 (0.54) | TRPC3TRPC6ALDH1A1KDM5ASMN1; SMN2 | |
| SCHEMBL4171049 | 0.80 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL4180264 | 0.80 | CCR3 (0.42) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL4177775 | 0.80 | ALDH1A1 (0.41) | MEN1KMT2ATRPC3TRPC6ALDH1A1 | |
| SCHEMBL3162739 | 0.80 | GAA (0.42) | MEN1KMT2AALDH1A1GAAPKM | |
| SCHEMBL3169856 | 0.79 | SCN3A (0.55) | MEN1KMT2AALDH1A1PKMGRIN2B | |
| SCHEMBL4173605 | 0.79 | NPC1 (0.41) | MEN1KMT2ATRPC3TRPC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357711-B2 | Heterocyclic sulfonamides as inhibitors of ion channels | PFIZER LIMITED (GB) | 2013-01-22 | — | — | US | disclosed |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPV5, TRPA1 | SPR 2567/4885MEN1 4729/4885KMT2A 1920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.