Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | WDR5 | P61964 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29599514 | 0.88 | NR4A1 (0.61) | NR4A1NR4A2NR4A3ALDH1A1KMT2A | |
| SCHEMBL68335 | 0.88 | NR4A1 (0.61) | NR4A1NR4A2NR4A3ALDH1A1KMT2A | |
| SCHEMBL28321692 | 0.87 | KMT2A (0.47) | ALDH1A1KMT2AMEN1KDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL21173945 | 0.86 | NR4A1 (0.59) | NR4A1NR4A2NR4A3ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL28890343 | 0.86 | NR4A1 (0.59) | NR4A1NR4A2NR4A3ALDH1A1KMT2A | |
| SCHEMBL4351479 | 0.80 | KMT2A (0.68) | NR4A1NR4A2NR4A3ALDH1A1KMT2A | |
| SCHEMBL2816321 | 0.79 | CYP2A6 (0.58) | ALDH1A1KMT2AHSD17B10MAPTATM | |
| SCHEMBL29699776 | 0.79 | CYP2A6 (0.58) | ALDH1A1KMT2AHSD17B10MAPTATM | |
| SCHEMBL6051302 | 0.79 | ACMSD (0.54) | NR4A1NR4A2NR4A3ALDH1A1KDM4E | |
| SCHEMBL11639473 | 0.78 | ALDH1A1 (0.58) | ALDH1A1KMT2AMEN1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989209-B1 | Aza-thia-benzazulene derivatives and pharmaceutical use thereof | NOVARTIS TIERGESUNDHEIT AG (CH) | 2015-03-25 | — | — | EP | disclosed |
| US-8258128-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-09-04 | — | — | US | disclosed |
| US-20090131408-A1 | Organic Compounds | NOVARTIS TIERGESUNDHEIT AG (CH) | 2009-05-21 | — | — | US | disclosed |
| EP-1989209-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007096150-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2007-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131408-A1 | Organic Compounds | IL1B, IL1A, TANK | NR4A1 570/4885NR4A2 382/4885NR4A3 598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.