Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.60 |
| ▸ | FNTA | P49354 | 1/20 | 0.58 |
| ▸ | FNTB | P49356 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | NOS3 | P29474 | 1/20 | 0.56 |
| ▸ | NOS1 | P29475 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4176971 | 0.89 | TSHR (0.64) | KDM4EALDH1A1HTR1ADRD2ALOX15 | |
| SCHEMBL4173376 | 0.87 | NOS3 (0.61) | KDM4EALDH1A1HTR1ADRD2FNTA | |
| SCHEMBL12120397 | 0.86 | ALDH1A1 (0.64) | KDM4EALDH1A1FNTAFNTBALOX15 | |
| SCHEMBL4176969 | 0.85 | DRD2 (0.60) | KDM4EALDH1A1HTR1ADRD2ALOX15 | |
| SCHEMBL5718112 | 0.84 | ALDH1A1 (0.67) | KDM4EALDH1A1FNTAFNTBMEN1 | |
| SCHEMBL4168265 | 0.83 | SLC6A3 (0.59) | HTR1ADRD2SIGMAR1 | |
| SCHEMBL18389960 | 0.83 | HSD11B1 (0.69) | KDM4EALDH1A1FNTAFNTBMEN1 | |
| SCHEMBL13621174 | 0.82 | FNTA (0.64) | KDM4EALDH1A1FNTAFNTBMEN1 | |
| SCHEMBL4836752 | 0.82 | KDM4E (0.54) | KDM4EALDH1A1HTR1ADRD2ALOX15 | |
| Bromide SCHEMBL4171916 | 0.82 | SLC6A3 (0.58) | HTR1ADRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090018118-A1 | HETEROCYCLIC COMPOUNDS | LEK PHARMACEUTICALS D.D. (SI) | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018118-A1 | HETEROCYCLIC COMPOUNDS | CYP51A1, DHCR7, LSS | KDM4E 2461/4885ALDH1A1 3225/4885HTR1A 2221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.