Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.61 |
| ▸ | NOS1 | P29475 | 1/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.57 |
| ▸ | FNTA | P49354 | 1/20 | 0.57 |
| ▸ | FNTB | P49356 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4183633 | 0.87 | KDM4E (0.70) | NOS3NOS1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL10339998 | 0.85 | ME2 (0.64) | NOS3NOS1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL4172158 | 0.84 | TDP1 (0.72) | SIGMAR1HTR1ADRD2 | |
| SCHEMBL6618441 | 0.84 | NOS3 (0.61) | NOS3NOS1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL27544651 | 0.83 | THRB (0.64) | KCNH2MEN1KMT2APOLBHTR1A | |
| SCHEMBL4840912 | 0.82 | P2RX7 (0.53) | KCNH2MEN1KMT2APOLBHTR1A | |
| SCHEMBL4161284 | 0.81 | KCNJ1 (0.52) | NOS3NOS1KCNH2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4832771 | 0.81 | P2RX7 (0.52) | KCNH2MEN1KMT2APOLBHTR1A | |
| SCHEMBL4169180 | 0.81 | SIGMAR1 (0.61) | KCNH2KMT2ASIGMAR1KCNJ1THRB | |
| Hydrochloric Acid SCHEMBL4840698 | 0.81 | P2RX7 (0.52) | KCNH2MEN1KMT2APOLBHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090018118-A1 | HETEROCYCLIC COMPOUNDS | LEK PHARMACEUTICALS D.D. (SI) | 2009-01-15 | — | — | US | disclosed |
| EP-1981849-A1 | HETEROCYCLIC COMPOUNDS | LEK Pharmaceuticals D.D. (SI) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007073935-A1 | HETEROCYCLIC COMPOUNDS | LEK PHARMACEUTICALS D.D. (SI) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018118-A1 | HETEROCYCLIC COMPOUNDS | CYP51A1, DHCR7, LSS | NOS3 1643/4885NOS1 2718/4885HSD11B1 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.