SCHEMBL4185273

SCHEMBL4185273

O=C(O)c1n[nH]c(C(F)(F)F)c1C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.44
HCAR2 Q8TDS4 11/20 0.42
KMT2A Q03164 1/20 0.36
TSHR P16473 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.33
ABCC8 Q09428 1/20 0.33
KCNJ11 Q14654 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15825699 0.80 HCAR2 (0.58) HCAR2
SCHEMBL27764731 0.80 HCAR2 (0.53) ALOX15HCAR2KMT2ATSHR
SCHEMBL570053 0.80 HCAR2 (0.50) HCAR2KMT2A
SCHEMBL9912568 0.74 ABCC8 (0.54) ALOX15HCAR2ABCC8KCNJ11
SCHEMBL32678646 0.73 HCAR2 (0.41) HCAR2KMT2ATSHR
SCHEMBL32678645 0.73 HCAR2 (0.41) HCAR2KMT2ATSHR
SCHEMBL29129797 0.72 HCAR2 (0.35) HCAR2
SCHEMBL4591235 0.71 GYS1 (0.51) ALOX15KMT2AL3MBTL1
SCHEMBL1929855 0.71 HCAR2 (0.34) HCAR2
SCHEMBL22578794 0.69 ALOX15 (0.35) ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026043973-A1 POLY-METHYLATED, FLUORINE-FREE SUPERHYDROPHOBIC COMPOSITIONS, METHODS, AND/OR USES THEREOF UNIVERSITY OF NORTH TEXAS (US) 2026-02-26 WO disclosed
US-20090143440-A1 Pyrazoles Useful in the Treatment of Inflammation BIOLIPOX AB (SE) 2009-06-04 US disclosed
US-20090143455-A1 Pyrazoles Useful in the Treatment of Inflammation BIOLIPOX AB (SE) 2009-06-04 US disclosed
EP-1937645-A1 PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION Biolipox AB (SE) 2008-07-02 EP disclosed
WO-2007045868-A1 PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION BIOLIPOX AB (SE) 2007-04-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090143440-A1 Pyrazoles Useful in the Treatment of Inflammation ALOX15, ALOX12, ALOX15B ALOX15 1/4885HCAR2 488/4885KMT2A 4450/4885
US-20090143455-A1 Pyrazoles Useful in the Treatment of Inflammation ALOX15, ALOX12, ALOX15B ALOX15 1/4885HCAR2 580/4885KMT2A 4432/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.