Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632639 | 0.89 | ROCK2 (0.42) | GBA1CSNK2A2CSNK2A1ROCK2RPS6KB1 | |
| SCHEMBL1630622 | 0.88 | GBA1 (0.41) | GBA1CSNK2A2CSNK2A1ROCK2RPS6KB1 | |
| SCHEMBL1631688 | 0.87 | GBA1 (0.42) | GBA1CSNK2A2CSNK2A1ROCK2RPS6KB1 | |
| SCHEMBL4179070 | 0.87 | ROCK2 (0.41) | GBA1CSNK2A2CSNK2A1ROCK2RPS6KB1 | |
| SCHEMBL1884309 | 0.81 | KDM4E (0.46) | GBA1CSNK2A2CSNK2A1RPS6KB1AKT1 | |
| SCHEMBL1632673 | 0.81 | GBA1 (0.47) | GBA1CSNK2A2CSNK2A1RPS6KB1AKT1 | |
| SCHEMBL1632162 | 0.80 | GBA1 (0.47) | GBA1CSNK2A2CSNK2A1RPS6KB1AKT1 | |
| SCHEMBL1631787 | 0.80 | GBA1 (0.51) | GBA1CSNK2A2CSNK2A1RPS6KB1AKT1 | |
| SCHEMBL4183068 | 0.80 | PTAFR (0.39) | GBA1CSNK2A2CSNK2A1NR3C2ADRB2 | |
| SCHEMBL13743506 | 0.79 | GBA1 (0.49) | GBA1CSNK2A2CSNK2A1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090198057-A1 | Certain Chemical Entities, Compositions, and Methods | CYTOKINETICS, INCORPORATED | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090198057-A1 | Certain Chemical Entities, Compositions, and Methods | MYLK, MYH2, MYH10 | GBA1 3801/4885CSNK2A2 534/4885CSNK2A1 714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.