SCHEMBL4186036

SCHEMBL4186036

C[C@@H](CC1CCCC1)NCc1ccccc1NS(=O)(=O)c1ccc2[nH]c(=O)ccc2c1

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
POLB P06746 7/20 0.52
OGT O15294 2/20 0.52
THRB P10828 2/20 0.51
PKM P14618 3/20 0.48
MAPT P10636 5/20 0.47
TP53 P04637 5/20 0.45
LMNA P02545 5/20 0.44
ALDH1A1 P00352 2/20 0.44
KDM4E B2RXH2 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4192891 0.99 POLB (0.52) POLBOGTTHRBPKMMAPT
SCHEMBL4194569 0.83 POLB (0.48) POLBTHRBPKMMAPTTP53
SCHEMBL4193848 0.83 PDE3A (0.46) POLBPKMMAPTTP53LMNA
SCHEMBL4188311 0.83 POLB (0.47) POLBTHRBPKMMAPTTP53
SCHEMBL4197689 0.83 POLB (0.47) POLBTHRBPKMMAPTTP53
SCHEMBL4197662 0.83 POLB (0.47) POLBTHRBPKMMAPTTP53
SCHEMBL4202106 0.83 PDE3A (0.46) POLBPKMMAPTTP53LMNA
SCHEMBL4194032 0.82 PKM (0.42) POLBTHRBPKMMAPTTP53
SCHEMBL4200065 0.82 KMT2A (0.42) POLBTHRBPKMMAPTTP53
SCHEMBL4193118 0.82 BRPF1 (0.51) PKMALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1879877-B1 ANTIMICROBIAL AGENTS RANBAXY LAB LTD (IN) 2013-01-02 EP claimed
US-8076370-B2 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2011-12-13 US claimed
US-20090215764-A1 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2009-08-27 US claimed
EP-1879877-B1 ANTIMICROBIAL AGENTS RANBAXY LAB LTD (IN) 2013-01-02 EP disclosed
US-8076370-B2 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2011-12-13 US disclosed
US-20090215764-A1 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2009-08-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090215764-A1 Antimicrobial agents TUFM, RPS17, HARS1 POLB 215/4885OGT 1548/4885THRB 1214/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.