Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 3/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4188739 | 0.85 | GLA (0.42) | GLAALDH1A1KMT2AHTTLMNA | |
| SCHEMBL4193735 | 0.77 | KDM4E (0.40) | BRD4ALDH1A1KMT2AHTTMEN1 | |
| SCHEMBL2418698 | 0.74 | ALDH1A1 (0.51) | ALDH1A1KMT2AHTTLMNAMEN1 | |
| SCHEMBL2412829 | 0.73 | SSTR3 (0.40) | KMT2AKDM4E | |
| SCHEMBL2209548 | 0.73 | HRH4 (0.38) | GLAALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL2418127 | 0.73 | ALDH1A1 (0.44) | ALDH1A1KMT2ALMNAMEN1HPGD | |
| SCHEMBL27468402 | 0.73 | SIGMAR1 (0.48) | BRD4KMT2AMEN1KDM1A | |
| SCHEMBL2418209 | 0.72 | MAPT (0.54) | ALDH1A1KMT2ALMNAMEN1MAPT | |
| SCHEMBL2417712 | 0.70 | NPC1 (0.46) | KMT2AHTTLMNAMEN1 | |
| SCHEMBL2962428 | 0.68 | EGFR (0.39) | GLAALDH1A1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071604-B2 | Thio-substituted arylmethanesulfinyl derivatives | CEPHALON FRANCE (FR) | 2011-12-06 | — | — | US | disclosed |
| US-20090018143-A1 | Thio-substituted arylmethanesulfinyl derivatives | CEPHALON, INC. (US) | 2009-01-15 | — | — | US | disclosed |
| US-7297817-B2 | Thio-substituted arylmethanesulfinyl derivatives | CEPHALON FRANCE (FR) | 2007-11-20 | — | — | US | disclosed |
| EP-1740535-A1 | THIO-SUBSTITUTED METHANESULFINYL DERIVATIVES | CEPHALON, INC. (US) | 2007-01-10 | — | — | EP | disclosed |
| US-20050256133-A1 | Thio-substituted arylmethanesulfinyl derivatives | CEPHALON FRANCE (FR) | 2005-11-17 | — | — | US | disclosed |
| WO-2005100310-A1 | THIO-SUBSTITUTED ARYLMETHANESULFINYL DERIVATIVES | CEPHALON INC. (US) | 2005-10-27 | — | — | WO | disclosed |
| EP-1586560-A1 | Thio-substituted arylmethanesulfinyl derivatives | CEPHALON, INC. (US) | 2005-10-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256133-A1 | Thio-substituted arylmethanesulfinyl derivatives | HTR1A, SLC6A3, HTR3B | GLA 4156/4885BRD4 827/4885ALDH1A1 1617/4885 |
| US-20090018143-A1 | Thio-substituted arylmethanesulfinyl derivatives | HTR1A, SLC6A3, HTR3B | GLA 4156/4885BRD4 827/4885ALDH1A1 1617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.