Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2207696 | 0.80 | TAAR1 (0.39) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL12433152 | 0.80 | PARP10 (0.41) | KDM4EALDH1A1KMT2ASIRT1MAPK8 | |
| SCHEMBL18323992 | 0.80 | TAAR1 (0.39) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL1196144 | 0.78 | KMT2A (0.46) | BCAT2KMT2ARAB9A | |
| SCHEMBL4188735 | 0.77 | GLA (0.38) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL6802553 | 0.76 | SIRT1 (0.36) | KDM4EALDH1A1HPGDMAPTTSHR | |
| SCHEMBL10398402 | 0.75 | CES2 (0.43) | MAPTTSHRHSD17B10MEN1KMT2A | |
| SCHEMBL29131294 | 0.75 | CES2 (0.43) | MAPTTSHRHSD17B10MEN1KMT2A | |
| SCHEMBL2211230 | 0.75 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDKMT2AGAA | |
| SCHEMBL2416330 | 0.74 | KDM4E (0.54) | KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071604-B2 | Thio-substituted arylmethanesulfinyl derivatives | CEPHALON FRANCE (FR) | 2011-12-06 | — | — | US | disclosed |
| US-20090018143-A1 | Thio-substituted arylmethanesulfinyl derivatives | CEPHALON, INC. (US) | 2009-01-15 | — | — | US | disclosed |
| US-7297817-B2 | Thio-substituted arylmethanesulfinyl derivatives | CEPHALON FRANCE (FR) | 2007-11-20 | — | — | US | disclosed |
| US-20050256133-A1 | Thio-substituted arylmethanesulfinyl derivatives | CEPHALON FRANCE (FR) | 2005-11-17 | — | — | US | disclosed |
| EP-1586560-A1 | Thio-substituted arylmethanesulfinyl derivatives | CEPHALON, INC. (US) | 2005-10-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256133-A1 | Thio-substituted arylmethanesulfinyl derivatives | HTR1A, SLC6A3, HTR3B | KDM4E 1433/4885ALDH1A1 1617/4885HPGD 3501/4885 |
| US-20090018143-A1 | Thio-substituted arylmethanesulfinyl derivatives | HTR1A, SLC6A3, HTR3B | KDM4E 1433/4885ALDH1A1 1617/4885HPGD 3501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.