Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP4 | P49662 | 1/20 | 0.36 |
| ▸ | CASP5 | P51878 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25027553 | 0.96 | HTR2A (0.42) | HTR2AKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL419964 | 0.82 | HTR3A (0.47) | KDM4EALDH1A1CYP1A2HRH4 | |
| SCHEMBL5524143 | 0.82 | ALDH1A1 (0.44) | HTR2AKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL20460055 | 0.82 | PIM2 (0.33) | HTR2AKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL15401271 | 0.79 | PIM2 (0.42) | KDM4EALDH1A1HPGDHSD17B10PIM2 | |
| SCHEMBL12186828 | 0.79 | CYP1A2 (0.42) | HTR2AKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL939716 | 0.75 | ALDH1A1 (0.70) | HTR2AKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9885016 | 0.75 | PDE10A (0.47) | HTR2AKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL18708528 | 0.75 | HRH4 (0.45) | HTR2AKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL31015264 | 0.75 | SMPD3 (0.39) | HTR2AKDM4EMEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250002475-A1 | PIPERIDINE DERIVATIVES AS METTL3 INHIBITORS | EPICS THERAPEUTICS (BE) | 2025-01-02 | — | — | US | disclosed |
| US-12091400-B2 | Piperidine derivatives as METTL3 inhibitors | EPICS THERAPEUTICS (BE) | 2024-09-17 | — | — | US | disclosed |
| US-20240270716-A1 | PIPERIDINE DERIVATIVES AS METTL3 INHIBITORS | EPICS THERAPEUTICS (BE) | 2024-08-15 | — | — | US | disclosed |
| US-11261200-B2 | Heteroaryltrifluoroborate compounds for the treatment of mycobacterial infections | THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC. (US) | 2022-03-01 | — | — | US | disclosed |
| CN-113620981-A | Heteroaryl trifluoroborate compounds for the treatment of mycobacterial infections | 结核病药物开发全球联盟公司 | 2021-11-09 | — | — | CN | disclosed |
| CN-110035661-B | Heteroaryl trifluoroborate compounds for the treatment of mycobacterial infections | 结核病药物开发全球联盟公司 | 2021-09-10 | — | — | CN | disclosed |
| CN-108137561-B | Indolin-2-one derivatives | 豪夫迈·罗氏有限公司 | 2021-03-26 | — | — | CN | disclosed |
| EP-3371174-B1 | INDOLIN-2-ONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2021-03-17 | — | — | EP | disclosed |
| US-20190276478-A1 | HETEROARYLTRIFLUOROBORATE COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC | 2019-09-12 | — | — | US | disclosed |
| US-20190276478-A1 | HETEROARYLTRIFLUOROBORATE COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC | 2019-09-12 | — | — | US | disclosed |
| CN-110035661-A | Heteroaryl trifluoroborate compounds for the treatment of mycobacterial infections | 结核病药物开发全球联盟公司 | 2019-07-19 | — | — | CN | disclosed |
| US-20180251450-A1 | INDOLIN-2-ONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2018-09-06 | — | — | US | disclosed |
| CN-108137561-A | Indolin-2-one derivative | 豪夫迈·罗氏有限公司 | 2018-06-08 | — | — | CN | disclosed |
| WO-2018067762-A2 | HETEROARYLTRIFLUOROBORATE COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC. (US) | 2018-04-12 | — | — | WO | disclosed |
| US-8404670-B2 | Histamine H3 inverse agonists and antagonists and methods of use thereof | SUNOVION PHARMACEUTICALS INC. (US) | 2013-03-26 | — | — | US | disclosed |
| US-20120022050-A1 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. | 2012-01-26 | — | — | US | disclosed |
| EP-2396327-A1 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | Sunovion Pharmaceuticals Inc. (US) | 2011-12-21 | — | — | EP | disclosed |
| US-8063032-B2 | Histamine H3 inverse agonists and antagonists and methods of use thereof | SUNOVION PHARMACEUTICALS INC. (US) | 2011-11-22 | — | — | US | disclosed |
| WO-2010093425-A1 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | SEPRACOR INC. (US) | 2010-08-19 | — | — | WO | disclosed |
| US-20100204214-A1 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240270716-A1 | PIPERIDINE DERIVATIVES AS METTL3 INHIBITORS | METTL3, METTL16, DIMT1 | HTR2A 893/4885KDM4E 872/4885MEN1 1196/4885 |
| US-20250002475-A1 | PIPERIDINE DERIVATIVES AS METTL3 INHIBITORS | METTL3, METTL16, DIMT1 | HTR2A 893/4885KDM4E 872/4885MEN1 1196/4885 |
| US-20180251450-A1 | INDOLIN-2-ONE DERIVATIVES | GRIN2B, GRIN2A, TPH2 | HTR2A 12/4885KDM4E 4207/4885MEN1 1532/4885 |
| US-11261200-B2 | Heteroaryltrifluoroborate compounds for the treatment of mycobacterial infections | FNTB, CYP2F1, SDHB | HTR2A 4644/4885KDM4E 3825/4885MEN1 2569/4885 |
| US-20100204214-A1 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | HRH3, HRH4, HRH2 | HTR2A 88/4885KDM4E 1889/4885MEN1 1057/4885 |
| US-20120022050-A1 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | HRH3, HRH4, HRH2 | HTR2A 88/4885KDM4E 1889/4885MEN1 1057/4885 |
| US-12091400-B2 | Piperidine derivatives as METTL3 inhibitors | METTL3, METTL16, DIMT1 | HTR2A 893/4885KDM4E 872/4885MEN1 1196/4885 |
| US-20190276478-A1 | HETEROARYLTRIFLUOROBORATE COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | FNTB, CYP2F1, SDHB | HTR2A 4644/4885KDM4E 3825/4885MEN1 2569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.