SCHEMBL4189891

SCHEMBL4189891

C[Si](C)(C)C#Cc1ccc(=O)oc1

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CTRC Q99895 1/20 0.35
GABRA1 P14867 2/20 0.34
GABRG2 P18507 2/20 0.34
GABRB3 P28472 2/20 0.34
GABRA5 P31644 2/20 0.34
GABRA3 P34903 2/20 0.34
GABRA2 P47869 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1306384 0.75 GABRA1 (0.38) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL1306505 0.73 APP (0.41) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL4183457 0.71 CTRC (0.34) CTRC
SCHEMBL1230904 0.70 GABRA1 (0.37) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL1487565 0.70 ALOX5 (0.39)
SCHEMBL2854252 0.69 CYP1A1 (0.44) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL6006591 0.68 FFAR1 (0.37) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL6006594 0.68 FFAR1 (0.37) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL19174201 0.67 CYP1A1 (0.48) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL440124 0.67 GRM5 (0.50) GABRA1GABRG2GABRB3GABRA5GABRA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1476416-B1 MULTIFUNCTIONAL MONOMERS AND THEIR USE IN MAKING CROSS-LINKED POLYMERS AND POROUS FILMS DOW GLOBAL TECHNOLOGIES LLC (US) 2015-12-30 EP disclosed
US-7635741-B2 Curable polyacetylenes used as dielectrics in making microelectronics such as integrated circuits DOW GLOBAL TECHNOLOGIES INC. 2009-12-22 US disclosed
EP-1476416-A2 MULTIFUNCTIONAL MONOMERS AND THEIR USE IN MAKING CROSS-LINKED POLYMERS AND POROUS FILMS DOW GLOBAL TECHNOLOGIES INC. (US) 2004-11-17 EP disclosed
US-20040053033-A1 Multifunctional monomers and their use in making cross-linked polymers and porous films NIU Q JASON (US) 2004-03-18 US disclosed
WO-2003068825-A2 MULTIFUNCTIONAL MONOMERS AND THEIR USE IN MAKING CROSS-LINKED POLYMERS AND POROUS FILMS DOW GLOBAL TECHNOLOGIES INC. (US) 2003-08-21 WO disclosed