Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 12/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.37 |
| ▸ | MGLL | Q99685 | 3/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18168138 | 0.76 | SMN1; SMN2 (0.44) | USP1SMN1; SMN2MAPT | |
| SCHEMBL1845750 | 0.74 | LMNA (0.41) | USP1SMN1; SMN2ALDH1A1GAAMAPT | |
| SCHEMBL18211896 | 0.74 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1GAAMAPT | |
| SCHEMBL4187292 | 0.72 | MARK3 (0.44) | PTGS1PTGS2MGLLFAAHSMN1; SMN2 | |
| SCHEMBL21904257 | 0.72 | USP1 (0.37) | USP1 | |
| SCHEMBL4190137 | 0.71 | PTGS1 (0.36) | PTGS1PTGS2MGLLFAAH | |
| SCHEMBL20740487 | 0.69 | PTGS1 (0.34) | PTGS1PTGS2MGLLFAAH | |
| SCHEMBL1845316 | 0.68 | POLB (0.39) | USP1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4639742 | 0.68 | MGLL (0.55) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL15301093 | 0.67 | MGLL (0.50) | PTGS1PTGS2MGLLFAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029145-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | Novartis Ag (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140222-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2007-12-06 | — | — | WO | disclosed |