Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7524518 | 0.91 | KDM4E (0.44) | KDM4EPARP1HTR1BSLC6A4HTR1A | |
| SCHEMBL7827780 | 0.84 | SLC6A4 (0.43) | PARP1SLC6A4HTR1ARAB9ASLC6A2 | |
| SCHEMBL31561756 | 0.84 | SLC6A4 (0.43) | PARP1SLC6A4HTR1ARAB9ASLC6A2 | |
| SCHEMBL13534211 | 0.83 | SLC6A4 (0.45) | KDM4EPARP1HTR1BSLC6A4HTR1A | |
| SCHEMBL13533397 | 0.80 | MCHR1 (0.45) | PARP1SLC6A4HTR1ATP53SLC6A2 | |
| SCHEMBL13533372 | 0.79 | SLC6A4 (0.43) | PARP1SLC6A4HTR1ASLC6A2HRH1 | |
| SCHEMBL7481895 | 0.79 | MTNR1A (0.58) | KDM4EHTR1BSLC6A4HTR1ATP53 | |
| SCHEMBL13533385 | 0.76 | PARP1 (0.41) | PARP1SLC6A4HTR1ARAB9ASLC6A2 | |
| SCHEMBL7519010 | 0.75 | HTR1A (0.38) | SLC6A4HTR1AMTNR1AHTR2A | |
| SCHEMBL5785526 | 0.74 | PARP1 (0.47) | KDM4EPARP1SLC6A4SLC6A2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090082582-A1 | Process For Preparing [2-(2,3- Dihydrobenzofuran - Or Benzofuran-7-Yloxy)Ethyl]-(3 -Cyclopent-1-Ylbenzyl)Amine Derivatives and Synthesis Intermediate | PIERRE FABRE MEDICAMENT (FR) | 2009-03-26 | — | — | US | disclosed |
| EP-1996570-A1 | PROCESS FOR PREPARING [2-(2,3-DIHYDROBENZOFURAN- OR BENZOFURAN-7-YLOXY)ETHYL]-(3-CYCLOPENT-1-YLBENZYL)AMINE DERIVATIVES AND SYNTHESIS INTERMEDIATE | Pierre Fabre Médicament S.A. (FR) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007104872-A1 | PROCESS FOR PREPARING [2-(2,3-DIHYDROBENZOFURAN- OR BENZOFURAN-7-YLOXY)ETHYL]-(3-CYCLOPENT-1-YLBENZYL)AMINE DERIVATIVES AND SYNTHESIS INTERMEDIATE | PIERRE FABRE MEDICAMENT (FR) | 2007-09-20 | — | — | WO | disclosed |
| US-7235568-B2 | 3-(cyclopenten-1-yl)-benzyl-or 3-(cyclopenten-1-yl)-heteroarylmethyl-amine derivatives and use thereof as medicines for treating schizophrenia | PIERRE FABRE MEDICAMENT (FR) | 2007-06-26 | — | — | US | disclosed |
| US-7163957-B2 | 3-(Cyclopenten-1-yl)-benzyl-or 3-(cyclopenten-1-yl)-heteroarylmethyl-amine derivatives and use thereof as medicines for treating schizophrenia | PIERRE FABRE MEDICAMENT (FR) | 2007-01-16 | — | — | US | disclosed |
| US-20060264471-A1 | 3-(cyclopenten-1-yl)-benzyl-or 3-(cyclopenten-1-yl)-heteroarylmethyl-amine derviatives and use thereof as medicines for treating schizophrenia | PIERRE FABRE MEDICAMENT (FR) | 2006-11-23 | — | — | US | disclosed |
| EP-1551821-B1 | 3-(CYCLOPENTEN-1-YL)-BENZYL- OR 3-(CYCLOPENTEN-1-YL)-HETEROARYLMETHYL-AMINE DERIVATIVES AND USE THEREOF AS MEDICINES FOR TREATING SCHIZOPHRENIA | PF MEDICAMENT (FR) | 2006-05-17 | — | — | EP | disclosed |
| US-20060014827-A1 | 3-(Cyclopenten-1-yl)-benzyl-or 3-(cyclopenten-1-yl)-heteroarylmethyl-amine derivatives and use thereof as medicines for treating schizophrenia | PIERRE FABRE MEDICAMENT (FR) | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264471-A1 | 3-(cyclopenten-1-yl)-benzyl-or 3-(cyclopenten-1-yl)-heteroarylmethyl-amine derviatives and use thereof as medicines for treating schizophrenia | CNR2, CNR1, DBH | KDM4E 2093/4885PARP1 4214/4885HTR1B 98/4885 |
| US-20090082582-A1 | Process For Preparing [2-(2,3- Dihydrobenzofuran - Or Benzofuran-7-Yloxy)Ethyl]-(3 -Cyclopent-1-Ylbenzyl)Amine Derivatives and Synthesis Intermediate | TAC3, NCAPD3, PAH | KDM4E 3219/4885PARP1 1632/4885HTR1B 1581/4885 |
| US-20060014827-A1 | 3-(Cyclopenten-1-yl)-benzyl-or 3-(cyclopenten-1-yl)-heteroarylmethyl-amine derivatives and use thereof as medicines for treating schizophrenia | CHRNA3, CHRNB3, CNR2 | KDM4E 3078/4885PARP1 4642/4885HTR1B 253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.