Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4191964 | 0.91 | KDM4E (0.47) | KDM4EHTR1BHTR1ASLC6A4TP53 | |
| SCHEMBL7519010 | 0.85 | HTR1A (0.38) | HTR1ASLC6A4MTNR1ADRD2HTR2A | |
| SCHEMBL7479640 | 0.77 | HTR1A (0.50) | HTR1ASLC6A4PARP1 | |
| SCHEMBL7481895 | 0.76 | MTNR1A (0.58) | KDM4EHTR1BHTR1ASLC6A4TP53 | |
| SCHEMBL9091731 | 0.76 | ALDH1A1 (0.43) | KDM4EHTR1ASLC6A4MTNR1ADRD2 | |
| SCHEMBL7522499 | 0.76 | MTNR1A (0.68) | KDM4ERAB9AMTNR1AHPGD | |
| SCHEMBL7516624 | 0.76 | ACHE (0.43) | KDM4EPARP1HPGDDRD2HTR2A | |
| SCHEMBL30465990 | 0.76 | ACHE (0.43) | KDM4EPARP1HPGDDRD2HTR2A | |
| SCHEMBL9093284 | 0.75 | GRIN2B (0.43) | KDM4EHTR1ASLC6A4MTNR1ADRD2 | |
| SCHEMBL31561756 | 0.75 | SLC6A4 (0.43) | HTR1ASLC6A4RAB9AMTNR1APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873993-B1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-02-20 | — | — | EP | disclosed |
| US-5919814-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 1999-07-06 | — | — | US | disclosed |
| EP-0873993-A1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-10-28 | — | — | EP | disclosed |